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Potential Cytoprotective Activity of Ozone Therapy in SARS-CoV-2/COVID-19.
Martínez-Sánchez, Gregorio; Schwartz, Adriana; Donna, Vincenzo Di.
  • Martínez-Sánchez G; Scientific advisor, Freelance, 60126 Ancona, Italy.
  • Schwartz A; Clinica Fiorela Madrid, 28035 Madrid, Spain.
  • Donna VD; Dama Salus Medical Center, 76125 Trani, Italy.
Antioxidants (Basel) ; 9(5)2020 May 06.
Article in English | MEDLINE | ID: covidwho-854062
Semantic information from SemMedBD (by NLM)
1. Ozone therapy TREATS COVID-19
Subject
Ozone therapy
Predicate
TREATS
Object
COVID-19
2. 2019 novel coronavirus CAUSES Complication
Subject
2019 novel coronavirus
Predicate
CAUSES
Object
Complication
3. Systemic Therapy COEXISTS_WITH Clinical Management
Subject
Systemic Therapy
Predicate
COEXISTS_WITH
Object
Clinical Management
4. Inflammation AFFECTS Virus Diseases
Subject
Inflammation
Predicate
AFFECTS
Object
Virus Diseases
5. Oxidative Stress AFFECTS Virus Diseases
Subject
Oxidative Stress
Predicate
AFFECTS
Object
Virus Diseases
6. Ozone INTERACTS_WITH interleukin-
Subject
Ozone
Predicate
INTERACTS_WITH
Object
interleukin-
7. Ozone INTERACTS_WITH GA-Binding Protein Transcription Factor|GABPA|NFE2L2
Subject
Ozone
Predicate
INTERACTS_WITH
Object
GA-Binding Protein Transcription Factor|GABPA|NFE2L2
8. Ozone therapy AFFECTS Equilibrium
Subject
Ozone therapy
Predicate
AFFECTS
Object
Equilibrium
9. Present COEXISTS_WITH Inflammatory disorder
Subject
Present
Predicate
COEXISTS_WITH
Object
Inflammatory disorder
10. Ozone therapy TREATS COVID-19
Subject
Ozone therapy
Predicate
TREATS
Object
COVID-19
11. 2019 novel coronavirus CAUSES Complication
Subject
2019 novel coronavirus
Predicate
CAUSES
Object
Complication
12. Systemic Therapy COEXISTS_WITH Clinical Management
Subject
Systemic Therapy
Predicate
COEXISTS_WITH
Object
Clinical Management
13. Inflammation AFFECTS Virus Diseases
Subject
Inflammation
Predicate
AFFECTS
Object
Virus Diseases
14. Oxidative Stress AFFECTS Virus Diseases
Subject
Oxidative Stress
Predicate
AFFECTS
Object
Virus Diseases
15. Ozone INTERACTS_WITH interleukin-1, beta
Subject
Ozone
Predicate
INTERACTS_WITH
Object
interleukin-1, beta
16. Ozone INTERACTS_WITH GA-Binding Protein Transcription Factor|GABPA|NFE2L2
Subject
Ozone
Predicate
INTERACTS_WITH
Object
GA-Binding Protein Transcription Factor|GABPA|NFE2L2
17. Ozone therapy AFFECTS Equilibrium
Subject
Ozone therapy
Predicate
AFFECTS
Object
Equilibrium
18. Present COEXISTS_WITH Inflammatory disorder
Subject
Present
Predicate
COEXISTS_WITH
Object
Inflammatory disorder
ABSTRACT
(1)

Background:

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) in China at the end of 2019 has caused a large global outbreak. Systemic ozone therapy (OT) could be potentially useful in the clinical management of several complications secondary to SARS-CoV-2. The rationale and mechanism of action has already been proven clinically in other viral infections and has been shown in research studies to be highly effective at decreasing organ damage mediated by inflammation and oxidative stress. This review summarizes the OT studies that illustrate the possible cytoprotective mechanism of action of ozone and its physiological by-products in target organs affected by SARS-CoV-2. (2)

Methods:

This review encompasses a total of 74 peer-reviewed original articles. It is mainly focused on ozone as a modulator of the NF-κ B/Nrf2 pathways and IL-6/IL-1ß expression. (3)

Results:

In experimental models and the few existent clinical studies, homeostasis of the free radical and antioxidant balance by OT was associated with a modulation of NF-κ B/Nrf2 balance and IL-6 and IL-1ß expression. These molecular mechanisms support the cytoprotective effects of OT against tissue damage present in many inflammatory diseases, including viral infections. (4)

Conclusions:

The potential cytoprotective role of OT in the management of organ damage induced by COVID-19 merits further research. Controlled clinical trials are needed.

Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Language: English Year: 2020

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Language: English Year: 2020
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