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The duration of infectiousness of individuals infected with SARS-CoV-2.
Walsh, Kieran A; Spillane, Susan; Comber, Laura; Cardwell, Karen; Harrington, Patricia; Connell, Jeff; Teljeur, Conor; Broderick, Natasha; de Gascun, Cillian F; Smith, Susan M; Ryan, Máirín; O'Neill, Michelle.
  • Walsh KA; Health Information and Quality Authority, Smithfield, Dublin 7, Ireland. Electronic address: kiwalsh@hiqa.ie.
  • Spillane S; Health Information and Quality Authority, Smithfield, Dublin 7, Ireland.
  • Comber L; Health Information and Quality Authority, Smithfield, Dublin 7, Ireland.
  • Cardwell K; Health Information and Quality Authority, Smithfield, Dublin 7, Ireland; Health Research Board Centre for Primary Care Research, Department of General Practice, Royal College of Surgeons in Ireland, 123 St. Stephens Green, Dublin 2, Ireland.
  • Harrington P; Health Information and Quality Authority, Smithfield, Dublin 7, Ireland.
  • Connell J; National Virus Reference Laboratory, University College Dublin, Belfield, Dublin 4, Ireland.
  • Teljeur C; Health Information and Quality Authority, Smithfield, Dublin 7, Ireland.
  • Broderick N; Health Information and Quality Authority, Smithfield, Dublin 7, Ireland.
  • de Gascun CF; National Virus Reference Laboratory, University College Dublin, Belfield, Dublin 4, Ireland.
  • Smith SM; Health Research Board Centre for Primary Care Research, Department of General Practice, Royal College of Surgeons in Ireland, 123 St. Stephens Green, Dublin 2, Ireland.
  • Ryan M; Health Information and Quality Authority, Smithfield, Dublin 7, Ireland; Department of Pharmacology & Therapeutics, Trinity College Dublin, Trinity Health Sciences, James Street, Dublin 8, Ireland.
  • O'Neill M; Health Information and Quality Authority, Smithfield, Dublin 7, Ireland.
J Infect ; 81(6): 847-856, 2020 12.
Article in English | MEDLINE | ID: covidwho-856877
ABSTRACT

OBJECTIVES:

To summarise the evidence on the duration of infectiousness of individuals in whom SARS-CoV-2 ribonucleic acid is detected.

METHODS:

A rapid review was undertaken in PubMed, Europe PubMed Central and EMBASE from 1 January 2020 to 26 August 2020.

RESULTS:

We identified 15 relevant studies, including 13 virus culture and 2 contact tracing studies. For 5 virus culture studies, the last day on which SARS-CoV-2 was isolated occurred within 10 days of symptom onset. For another 5 studies, SARS-CoV-2 was isolated beyond day 10 for approximately 3% of included patients. The remaining 3 virus culture studies included patients with severe or critical disease; SARS-CoV-2 was isolated up to day 32 in one study. Two studies identified immunocompromised patients from whom SARS-CoV-2 was isolated for up to 20 days. Both contact tracing studies, when close contacts were first exposed greater than 5 days after symptom onset in the index case, found no evidence of laboratory-confirmed onward transmission of SARS-CoV-2.

CONCLUSION:

COVID-19 patients with mild-to-moderate illness are highly unlikely to be infectious beyond 10 days of symptoms. However, evidence from a limited number of studies indicates that patients with severe-to-critical illness or who are immunocompromised, may shed infectious virus for longer.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: RNA, Viral / Disease Transmission, Infectious / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study / Reviews Topics: Long Covid Limits: Humans Language: English Journal: J Infect Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: RNA, Viral / Disease Transmission, Infectious / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study / Reviews Topics: Long Covid Limits: Humans Language: English Journal: J Infect Year: 2020 Document Type: Article