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The Impact of COVID-19 Disease on Platelets and Coagulation.
Wool, Geoffrey D; Miller, Jonathan L.
  • Wool GD; Department of Pathology, University of Chicago, Chicago, Illinois, USA, Geoffrey.Wool@uchospitals.edu.
  • Miller JL; Department of Pathology, University of Chicago, Chicago, Illinois, USA.
Pathobiology ; 88(1): 15-27, 2021.
Article in English | MEDLINE | ID: covidwho-858185
ABSTRACT
Coronavirus disease 2019 (COVID-19) causes a spectrum of disease; some patients develop a severe proinflammatory state which can be associated with a unique coagulopathy and procoagulant endothelial phenotype. Initially, COVID-19 infection produces a prominent elevation of fibrinogen and D-dimer/fibrin(ogen) degradation products. This is associated with systemic hypercoagulability and frequent venous thromboembolic events. The degree of D-dimer elevation positively correlates with mortality in COVID-19 patients. COVID-19 also leads to arterial thrombotic events (including strokes and ischemic limbs) as well as microvascular thrombotic disorders (as frequently documented at autopsy in the pulmonary vascular beds). COVID-19 patients often have mild thrombocytopenia and appear to have increased platelet consumption, together with a corresponding increase in platelet production. Disseminated intravascular coagulopathy (DIC) and severe bleeding events are uncommon in COVID-19 patients. Here, we review the current state of knowledge of COVID-19 and hemostasis.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Blood Coagulation Disorders / Blood Platelets / SARS-CoV-2 / COVID-19 Type of study: Experimental Studies Topics: Long Covid Limits: Humans Language: English Journal: Pathobiology Journal subject: Pathology Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Blood Coagulation Disorders / Blood Platelets / SARS-CoV-2 / COVID-19 Type of study: Experimental Studies Topics: Long Covid Limits: Humans Language: English Journal: Pathobiology Journal subject: Pathology Year: 2021 Document Type: Article