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Unfractionated Heparin in SARS-CoV-2 Pneumonia: Ischemic Stroke Case Report.
Efendizade, Aslan; Dmytriw, Adam A; Hewitt, Kevin; Davies, Gwynivere A.
  • Efendizade A; Department of Diagnostic Radiology, State University of New York (SUNY) Downstate Medical Center, University Hospital Brooklyn, Brooklyn, NY, United States.
  • Dmytriw AA; Department of Medical Imaging, University of Toronto, Toronto, ON, Canada.
  • Hewitt K; Department of Neuroradiology & Neurointervention, Brigham and Women's Hospital, Boston, MA, United States.
  • Davies GA; Department of Diagnostic Radiology, State University of New York (SUNY) Downstate Medical Center, University Hospital Brooklyn, Brooklyn, NY, United States.
Front Neurol ; 11: 573356, 2020.
Article in English | MEDLINE | ID: covidwho-862010
Semantic information from SemMedBD (by NLM)
1. heparin ASSOCIATED_WITH Pneumonia
Subject
heparin
Predicate
ASSOCIATED_WITH
Object
Pneumonia
2. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
3. Thromboembolism PROCESS_OF Patients
Subject
Thromboembolism
Predicate
PROCESS_OF
Object
Patients
4. Thrombophilia CAUSES Acute Cerebrovascular Accidents
Subject
Thrombophilia
Predicate
CAUSES
Object
Acute Cerebrovascular Accidents
5. Infarction PROCESS_OF Patients
Subject
Infarction
Predicate
PROCESS_OF
Object
Patients
6. heparin TREATS Pneumonia
Subject
heparin
Predicate
TREATS
Object
Pneumonia
7. Pneumonia PROCESS_OF Patients
Subject
Pneumonia
Predicate
PROCESS_OF
Object
Patients
8. Discontinued CAUSES Thromboembolism
Subject
Discontinued
Predicate
CAUSES
Object
Thromboembolism
9. heparin ASSOCIATED_WITH Pneumonia
Subject
heparin
Predicate
ASSOCIATED_WITH
Object
Pneumonia
10. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
11. Thromboembolism PROCESS_OF Patients
Subject
Thromboembolism
Predicate
PROCESS_OF
Object
Patients
12. Thrombophilia CAUSES Acute Cerebrovascular Accidents
Subject
Thrombophilia
Predicate
CAUSES
Object
Acute Cerebrovascular Accidents
13. Infarction PROCESS_OF Patients
Subject
Infarction
Predicate
PROCESS_OF
Object
Patients
14. heparin TREATS Pneumonia
Subject
heparin
Predicate
TREATS
Object
Pneumonia
15. Pneumonia PROCESS_OF Patients
Subject
Pneumonia
Predicate
PROCESS_OF
Object
Patients
16. Discontinued CAUSES Thromboembolism
Subject
Discontinued
Predicate
CAUSES
Object
Thromboembolism
ABSTRACT
Thromboembolism is a known phenomenon in patients with Coronavirus disease 2019 (COVID-19). Recent investigations have revealed that a significant proportion of those hospitalized with severe COVID-19 demonstrate clinical and laboratory markers compatible with hypercoagulability, which is differentiated from disseminated intravascular coagulation (DIC), termed COVID-associated coagulopathy. Additionally, there is increasing concern for development of acute ischemic stroke because of this hypercoagulable state. We present a patient with COVID-19 pneumonia who was managed with unfractionated heparin (UFH) infusion and developed a large ischemic infarct shortly after cessation of the infusion. In retrospect, the patient's coagulation parameters were consistent with overt DIC, although some of these parameters are easily masked by the effects of UFH. These findings emphasize the importance of anticoagulation as well as its careful discontinuation, as failure to do so may result in a significant thromboembolic event.
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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Type of study: Case report Language: English Journal: Front Neurol Year: 2020

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Type of study: Case report Language: English Journal: Front Neurol Year: 2020
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