Ethics of Conducting Clinical Research in an Outbreak Setting.
Annu Rev Virol
; 7(1): 475-494, 2020 09 29.
Article
in English
| MEDLINE | ID: covidwho-865856
ABSTRACT
The conduct of clinical trials during the West Africa Ebola outbreak in 2014 highlighted many ethical challenges. How these challenges were addressed, what clinical studies were conducted during that outbreak, and the lessons learned for dealing with future outbreaks were the subject of a National Academy of Medicine committee report titled Integrating Clinical Research into Epidemic Response The Ebola Experience. This report suggested improvements for research during subsequent emerging or re-emerging outbreaks and is summarized in this review. We also discuss the current Ebola outbreak in the Democratic Republic of the Congo and highlight how the dialogue has changed and how successful clinical trials have been implemented. We conclude with a description of productive efforts to include pregnant women and children in therapeutic and vaccine trials during outbreaks that are currently ongoing.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Disease Outbreaks
/
Clinical Trials as Topic
/
Patient Selection
/
Hemorrhagic Fever, Ebola
/
Biomedical Research
/
Ebolavirus
Type of study:
Observational study
/
Prognostic study
/
Randomized controlled trials
Topics:
Vaccines
Limits:
Adult
/
Child
/
Female
/
Humans
/
Male
/
Pregnancy
Country/Region as subject:
Africa
Language:
English
Journal:
Annu Rev Virol
Year:
2020
Document Type:
Article
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