Analgesia and Sedation Strategies in Mechanically Ventilated Adults with COVID-19.
Pharmacotherapy
; 40(12): 1180-1191, 2020 12.
Article
in English
| MEDLINE | ID: covidwho-866159
ABSTRACT
Evidence-based management of analgesia and sedation in COVID-19-associated acute respiratory distress syndrome remains limited. Non-guideline recommended analgesic and sedative medication regimens and deeper sedation targets have been employed for patients with COVID-19 due to exaggerated analgesia and sedation requirements with extended durations of mechanical ventilation. This, coupled with a desire to minimize nurse entry into COVID-19 patient rooms, marked obesity, altered end-organ function, and evolving medication shortages, presents numerous short- and long-term challenges. Alternative analgesic and sedative agents and regimens may pose safety risks and require judicious bedside management for appropriate use. The purpose of this commentary is to provide considerations and solutions for designing safe and effective analgesia and sedation strategies for adult patients with considerable ventilator dyssynchrony and sedation requirements, such as COVID-19.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Respiration, Artificial
/
Evidence-Based Medicine
/
COVID-19
/
COVID-19 Drug Treatment
/
Analgesics
/
Hypnotics and Sedatives
Type of study:
Prognostic study
Topics:
Long Covid
Limits:
Humans
Language:
English
Journal:
Pharmacotherapy
Year:
2020
Document Type:
Article
Affiliation country:
Phar.2471
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