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Lack of tocilizumab effect on mortality in COVID19 patients.
Holt, Gregory E; Batra, Mayank; Murthi, Mukunthan; Kambali, Shweta; Santos, Kayo; Bastidas, Maria Virginia Perez; Asif, Huda; Haddadi, Sara; Arias, Sixto; Mirsaeidi, Mehdi.
  • Holt GE; Division of Pulmonary and Critical Care, University of Miami, Miami, FL, USA.
  • Batra M; Division of Pulmonary and Critical Care, University of Miami, Miami, FL, USA.
  • Murthi M; Division of Pulmonary and Critical Care, University of Miami, Miami, FL, USA.
  • Kambali S; Division of Pulmonary and Critical Care, University of Miami, Miami, FL, USA.
  • Santos K; Division of Pulmonary and Critical Care, University of Miami, Miami, FL, USA.
  • Bastidas MVP; Division of Pulmonary and Critical Care, University of Miami, Miami, FL, USA.
  • Asif H; Division of Pulmonary and Critical Care, University of Miami, Miami, FL, USA.
  • Haddadi S; Division of Pulmonary and Critical Care, University of Miami, Miami, FL, USA.
  • Arias S; Division of Pulmonary and Critical Care, University of Miami, Miami, FL, USA.
  • Mirsaeidi M; Division of Pulmonary and Critical Care, University of Miami, Miami, FL, USA. msm249@med.miami.edu.
Sci Rep ; 10(1): 17100, 2020 10 13.
Article in English | MEDLINE | ID: covidwho-867596
ABSTRACT
Off-label tocilizumab use in COVID-19 patients reflects concern for cytokine release syndrome. Comparison of matched COVID-19 pneumonia patients found elevated IL-6 levels correlated with mortality that did not change with tocilizumab administration. Correlating mortality with increased IL-6 doesn't imply causality however lack of improvement by tocilizumab requires further clinical trial alterations.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Antibodies, Monoclonal, Humanized Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Sci Rep Year: 2020 Document Type: Article Affiliation country: S41598-020-74328-x

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Antibodies, Monoclonal, Humanized Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Sci Rep Year: 2020 Document Type: Article Affiliation country: S41598-020-74328-x