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Coagulopathy, endothelial dysfunction, thrombotic microangiopathy and complement activation: potential role of complement system inhibition in COVID-19.
Wang, Xin; Sahu, Kamal Kant; Cerny, Jan.
  • Wang X; Department of Medicine, UMass Memorial Health Care, University of Massachusetts Medical School, Worcester, MA, USA.
  • Sahu KK; Department of Internal Medicine, Saint Vincent Hospital, Worcester, MA, 01608, USA.
  • Cerny J; Department of Medicine - Hematology, and Oncology, UMass Memorial Medical Center, University of Massachusetts Medical School, Worcester, MA, USA. jan.cerny@umassmemorial.org.
J Thromb Thrombolysis ; 51(3): 657-662, 2021 Apr.
Article in English | MEDLINE | ID: covidwho-871528
ABSTRACT
Coronavirus disease-2019 (COVID-19) is a rapidly evolving health crisis caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is a novel disease entity and we are in a learning phase with regards to the pathogenesis, disease manifestations, and therapeutics. In addition to the primary lung injury, many patients especially the ones with moderate to severe COVID-19 display evidence of endothelial damage, complement activation, which leads to a pro-coagulable state. While there are still missing links in our understanding, the interplay of endothelium, complement system activation, and immune response to the SARS-CoV-2 virus is a surprisingly major factor in COVID-19 pathogenesis. One could envision COVID-19 becoming a novel hematological syndrome. This review is to discuss the available literature with regards to the involvement of the complement system, and coagulation cascade and their interaction with endothelium.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Endothelium, Vascular / Complement Activation / Thrombotic Microangiopathies / COVID-19 Topics: Long Covid Limits: Humans Language: English Journal: J Thromb Thrombolysis Journal subject: Vascular Diseases Year: 2021 Document Type: Article Affiliation country: S11239-020-02297-z

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Endothelium, Vascular / Complement Activation / Thrombotic Microangiopathies / COVID-19 Topics: Long Covid Limits: Humans Language: English Journal: J Thromb Thrombolysis Journal subject: Vascular Diseases Year: 2021 Document Type: Article Affiliation country: S11239-020-02297-z