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Gold/Silver Hybrid Nanoparticles with Enduring Inhibition of Coronavirus Multiplication through Multisite Mechanisms.
Du, Ting; Zhang, Jinyu; Li, Chunqiao; Song, Tao; Li, Ping; Liu, Jifeng; Du, Xinjun; Wang, Shuo.
  • Du T; State Key Laboratory of Food Nutrition and Safety, College of Food Science and Engineering, Demonstration Center of Food Quality and Safety Testing Technology, Tianjin University of Science and Technology, Tianjin 300457, China.
  • Zhang J; State Key Laboratory of Food Nutrition and Safety, College of Food Science and Engineering, Demonstration Center of Food Quality and Safety Testing Technology, Tianjin University of Science and Technology, Tianjin 300457, China.
  • Li C; State Key Laboratory of Food Nutrition and Safety, College of Food Science and Engineering, Demonstration Center of Food Quality and Safety Testing Technology, Tianjin University of Science and Technology, Tianjin 300457, China.
  • Song T; Hebei Key Laboratory of Preventive Veterinary Medicine, College of Animal Science and Technology, Hebei Normal University of Science and Technology, Qinhuangdao, Hebei 066000, China.
  • Li P; State Key Laboratory of Food Nutrition and Safety, College of Food Science and Engineering, Demonstration Center of Food Quality and Safety Testing Technology, Tianjin University of Science and Technology, Tianjin 300457, China.
  • Liu J; State Key Laboratory of Food Nutrition and Safety, College of Food Science and Engineering, Demonstration Center of Food Quality and Safety Testing Technology, Tianjin University of Science and Technology, Tianjin 300457, China.
  • Du X; State Key Laboratory of Food Nutrition and Safety, College of Food Science and Engineering, Demonstration Center of Food Quality and Safety Testing Technology, Tianjin University of Science and Technology, Tianjin 300457, China.
  • Wang S; State Key Laboratory of Food Nutrition and Safety, College of Food Science and Engineering, Demonstration Center of Food Quality and Safety Testing Technology, Tianjin University of Science and Technology, Tianjin 300457, China.
Bioconjug Chem ; 31(11): 2553-2563, 2020 11 18.
Article in English | MEDLINE | ID: covidwho-872629
Semantic information from SemMedBD (by NLM)
1. Hybrids LOCATION_OF colloidal silver
Subject
Hybrids
Predicate
LOCATION_OF
Object
colloidal silver
2. Hybrids LOCATION_OF colloidal silver
Subject
Hybrids
Predicate
LOCATION_OF
Object
colloidal silver
ABSTRACT
As a large enveloped RNA virus, coronavirus is of considerable medical and veterinary significance, and anticoronavirus treatment is challenging due to its biodiversity and rapid variability. In this study, Au@Ag nanorods (Au@AgNRs) were successfully synthesized by coating AuNRs with silver and were shown for the first time to have activity against the replication of porcine epidemic diarrhea virus (PEDV). Viral titer analysis demonstrated that Au@AgNRs could inhibit PEDV infection by 4 orders of magnitude at 12 h post-infection, which was verified by viral protein expression analysis. The potential mechanism of action showed that Au@AgNRs could inhibit the entry of PEDV and decrease the mitochondrial membrane potential and caspase-3 activity. Additionally, we demonstrated that a large amount of virus proliferation can cause the generation of reactive oxygen species in cells, and the released Ag+ and exposed AuNRs by Au@AgNRs after the stimulation of reactive oxygen species has superior antiviral activity to ensure long-term inhibition of the PEDV replication cycle. The integrated results support that Au@AgNRs can serve as a potential therapeutic strategy to prevent the replication of coronavirus.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Silver / Virus Replication / Porcine epidemic diarrhea virus / Metal Nanoparticles / Gold Subject: Silver / Virus Replication / Porcine epidemic diarrhea virus / Metal Nanoparticles / Gold Language: English Journal: Bioconjug Chem Year: 2020

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Silver / Virus Replication / Porcine epidemic diarrhea virus / Metal Nanoparticles / Gold Subject: Silver / Virus Replication / Porcine epidemic diarrhea virus / Metal Nanoparticles / Gold Language: English Journal: Bioconjug Chem Year: 2020
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