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Identifying SARS-CoV-2 Entry Inhibitors through Drug Repurposing Screens of SARS-S and MERS-S Pseudotyped Particles.
Chen, Catherine Z; Xu, Miao; Pradhan, Manisha; Gorshkov, Kirill; Petersen, Jennifer D; Straus, Marco R; Zhu, Wei; Shinn, Paul; Guo, Hui; Shen, Min; Klumpp-Thomas, Carleen; Michael, Samuel G; Zimmerberg, Joshua; Zheng, Wei; Whittaker, Gary R.
  • Chen CZ; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States.
  • Xu M; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States.
  • Pradhan M; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States.
  • Gorshkov K; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States.
  • Petersen JD; Section on Integrative Biophysics, Division of Basic and Translational Biophysics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, United States.
  • Straus MR; Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, United States.
  • Zhu W; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States.
  • Shinn P; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States.
  • Guo H; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States.
  • Shen M; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States.
  • Klumpp-Thomas C; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States.
  • Michael SG; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States.
  • Zimmerberg J; Section on Integrative Biophysics, Division of Basic and Translational Biophysics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, United States.
  • Zheng W; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States.
  • Whittaker GR; Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, United States.
ACS Pharmacol Transl Sci ; 3(6): 1165-1175, 2020 Dec 11.
Article in English | MEDLINE | ID: covidwho-872651
Preprint
This scientific journal article is probably based on a previously available preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
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ABSTRACT
While vaccine development will hopefully quell the global pandemic of COVID-19 caused by SARS-CoV-2, small molecule drugs that can effectively control SARS-CoV-2 infection are urgently needed. Here, inhibitors of spike (S) mediated cell entry were identified in a high throughput screen of an approved drugs library with SARS-S and MERS-S pseudotyped particle entry assays. We discovered six compounds (cepharanthine, abemaciclib, osimertinib, trimipramine, colforsin, and ingenol) to be broad spectrum inhibitors for spike-mediated entry. This work could contribute to the development of effective treatments against the initial stage of viral infection and provide mechanistic information that might aid the design of new drug combinations for clinical trials for COVID-19 patients.

Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Topics: Vaccines Language: English Journal: ACS Pharmacol Transl Sci Year: 2020 Document Type: Article Affiliation country: Acsptsci.0c00112

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Topics: Vaccines Language: English Journal: ACS Pharmacol Transl Sci Year: 2020 Document Type: Article Affiliation country: Acsptsci.0c00112