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Reliability of induced sputum test is greater than that of throat swab test for detecting SARS-CoV-2 in patients with COVID-19: A multi-center cross-sectional study.
Lai, Tianwen; Xiang, Fangfei; Zeng, Jianfeng; Huang, Yingzi; Jia, Liping; Chen, Hui; Wu, Jiayuan; Xie, Jianfeng; Liu, Shuna; Deng, Wei; Zheng, Weiqiang; Huang, Yang; Zhang, Qinfu; Luo, Qingfeng; Mo, Fan; Long, Lieming; Zhang, Wuying; Chen, Wenna; Han, Huanqin.
  • Lai T; Department of Pulmonary and Critical Care Medicine, Affiliated Hospital of Guangdong Medical University , Zhanjiang, Guangdong, China.
  • Xiang F; Infectious Disease Center, Guangzhou Eighth People's Hospital, Guangzhou Medical University , Guangzhou, Guangdong, China.
  • Zeng J; Department of Pulmonary Medicine and Tuberculosis, The Third People's Hospital of Shenzhen , Shenzhen, Guangdong, China.
  • Huang Y; Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University , Nanjing, Jiangsu, China.
  • Jia L; Department of Respiratory Medicine, Huanggang Central Hospital , Huanggang, Hubei, China.
  • Chen H; Department of Intensive Care Medicine, The First Affiliated Hospital of Soochow University , Suzhou, Jiangsu, China.
  • Wu J; Department of Clinical Research, Affiliated Hospital of Guangdong Medical University , Zhanjiang, Guangdong, China.
  • Xie J; Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University , Nanjing, Jiangsu, China.
  • Liu S; Infectious Diseases Center, Affiliated Hospital of Guangdong Medical University , Zhanjiang, Guangdong, China.
  • Deng W; Infectious Diseases Center, Affiliated Hospital of Guangdong Medical University , Zhanjiang, Guangdong, China.
  • Zheng W; Infectious Diseases Center, Affiliated Hospital of Guangdong Medical University , Zhanjiang, Guangdong, China.
  • Huang Y; Infectious Diseases Center, Affiliated Hospital of Guangdong Medical University , Zhanjiang, Guangdong, China.
  • Zhang Q; Infectious Diseases Center, Affiliated Hospital of Guangdong Medical University , Zhanjiang, Guangdong, China.
  • Luo Q; Infectious Diseases Center, Affiliated Hospital of Guangdong Medical University , Zhanjiang, Guangdong, China.
  • Mo F; Infectious Diseases Center, Affiliated Hospital of Guangdong Medical University , Zhanjiang, Guangdong, China.
  • Long L; Infectious Diseases Center, Affiliated Hospital of Guangdong Medical University , Zhanjiang, Guangdong, China.
  • Zhang W; Infectious Diseases Center, Affiliated Hospital of Guangdong Medical University , Zhanjiang, Guangdong, China.
  • Chen W; Infectious Diseases Center, Affiliated Hospital of Guangdong Medical University , Zhanjiang, Guangdong, China.
  • Han H; Infectious Diseases Center, Affiliated Hospital of Guangdong Medical University , Zhanjiang, Guangdong, China.
Virulence ; 11(1): 1394-1401, 2020 12.
Article in English | MEDLINE | ID: covidwho-872896
ABSTRACT
We previously reported that sputum induction was more sensitive than throat swabs for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in two convalescent coronavirus disease 2019 (COVID-19) patients; however, the value and safety of induced sputum testing require further study. We conducted a prospective multi-center cross-sectional study to compare induced sputum to throat swabs for SARS-CoV-2 detection. Confirmed COVID-19 patients from six hospitals in six cities across China who received one or more negative RT-PCR result for SARS-CoV-2 were enrolled, and paired specimens (induced sputum and throat swabs; 56 cases) were assayed. In three paired samples, both the induced sputum and throat swabs were positive for SARS-CoV-2. The positive rate for induced sputum was significantly higher than for throat swabs both overall (28.6% vs 5.4%, respectively; p < 0.01). Patients were divided according to time span from onset of illness to sample collection into the more-than-30-day (n = 26) and less-than-30-day (n = 30) groups. The positive rate for induced sputum was also significantly higher than for throat swabs in the less-than-30-day group (53.3% vs 10.0%, respectively; p < 0.001). For the more-than-30-day group, all paired samples were negative for SARS-CoV-2. Blood oxygen saturation, respiratory rate, and heart rate remained stable during sputum induction and no staff were infected. Because induced sputum is more reliable and has a lower false-negative rate than throat swabs, we believe induced sputum is more useful for the confirmation of COVID-19 and is safer as a criterion for release from quarantine.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Sputum / Coronavirus Infections / Clinical Laboratory Techniques / Betacoronavirus Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Asia Language: English Journal: Virulence Year: 2020 Document Type: Article Affiliation country: 21505594.2020.1831342

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Sputum / Coronavirus Infections / Clinical Laboratory Techniques / Betacoronavirus Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Asia Language: English Journal: Virulence Year: 2020 Document Type: Article Affiliation country: 21505594.2020.1831342