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Retinal findings in hospitalised patients with severe COVID-19.
Pereira, Leonardo Amarante; Soares, Larissa Caroline Mansano; Nascimento, Priscila Alves; Cirillo, Luciano Rabello Netto; Sakuma, Hebert Toshiaki; Veiga, Glaucia Luciano da; Fonseca, Fernando Luiz Afonso; Lima, Vagner Loduca; Abucham-Neto, Julio Zaki.
  • Pereira LA; Discipline of Ophthalmology, Faculdade de Medicina do ABC, Santo Andre, Brazil leonardoxamarante@hotmail.com.
  • Soares LCM; Discipline of Ophthalmology, Faculdade de Medicina do ABC, Santo Andre, Brazil.
  • Nascimento PA; Discipline of Ophthalmology, Faculdade de Medicina do ABC, Santo Andre, Brazil.
  • Cirillo LRN; Discipline of Ophthalmology, Faculdade de Medicina do ABC, Santo Andre, Brazil.
  • Sakuma HT; Discipline of Ophthalmology, Faculdade de Medicina do ABC, Santo Andre, Brazil.
  • Veiga GLD; Discipline of Ophthalmology, Faculdade de Medicina do ABC, Santo Andre, Brazil.
  • Fonseca FLA; Clinical Analysis Laboratory, Faculdade de Medicina do ABC, Santo Andre, Brazil.
  • Lima VL; Discipline of Ophthalmology, Faculdade de Medicina do ABC, Santo Andre, Brazil.
  • Abucham-Neto JZ; Clinical Analysis Laboratory, Faculdade de Medicina do ABC, Santo Andre, Brazil.
Br J Ophthalmol ; 106(1): 102-105, 2022 01.
Article in English | MEDLINE | ID: covidwho-873488
ABSTRACT

AIM:

To identify retinal findings using dilated eye examination, which are possibly related to SARS-CoV-2 infection in hospitalised patients with confirmed severe COVID-19.

METHODS:

In this cross-sectional study, hospitalised patients with confirmed severe COVID-19 in a single referral centre for the treatment of COVID-19, in Santo André, São Paulo Metropolitan Area, Brazil, underwent dilated eye examination of both eyes performed by a retina specialist. Findings were recorded using a portable digital fundus camera. Retinographies were analysed by two retina specialists. Medical records were reviewed for assessment of patient demographics, baseline comorbidities and clinical data.

RESULTS:

There were a total of 18 patients, nine (50%) male, median IQR age of 62.5 (12) years. Ten of the 18 patients (55.6%; 95% CI 33.7 to 75.4) had abnormalities on dilated eye examination. The main findings were flame-shaped haemorrhages (N=4; 22.2%; 95% CI 9.0 to 45.2) and ischaemic pattern lesions (cotton wool spots and retinal sectorial pallor) (N=4; 22.2%; 95% CI 9.0 to 45.2), with one patient having both cotton wool spots and flame-shaped haemorrhages.

CONCLUSION:

These findings suggest that patients with severe COVID-19 have acute vascular lesions of the inner retina including flame-shaped haemorrhages and cotton wool spots. Further studies controlling for confounding factors are necessary to properly assess these findings so as to increase the understanding of COVID-19 pathophysiology and to identify new therapies.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Retina / Retinal Hemorrhage / Eye Infections, Viral / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: South America / Brazil Language: English Journal: Br J Ophthalmol Year: 2022 Document Type: Article Affiliation country: Bjophthalmol-2020-317576

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Retina / Retinal Hemorrhage / Eye Infections, Viral / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: South America / Brazil Language: English Journal: Br J Ophthalmol Year: 2022 Document Type: Article Affiliation country: Bjophthalmol-2020-317576