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Platelet aggregates, a marker of severe COVID-19 disease.
Rampotas, Alexandros; Pavord, Sue.
  • Rampotas A; Haematology Department, Oxford University Hospitals NHS Foundation Trust, Oxford, UK alexandros.rampotas@ouh.nhs.uk.
  • Pavord S; Haematology Department, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
J Clin Pathol ; 74(11): 750-751, 2021 Nov.
Article in English | MEDLINE | ID: covidwho-873566
ABSTRACT
Thrombocytopenia is common in an intensive care unit (ICU) setting due to endogenous and iatrogenic factors. Despite that, thrombocytopenia in patients with severe COVID-19 infections is surprisingly uncommon. By examining the blood film of 20 ICU patients with COVID-19, we observed the presence of platelet aggregates and macrothrombocytes indicating increased platelet activity. We compared these findings with 20 blood films of non-severe COVID-19 cases where these findings were absent. These morphology features could be consistent with severe COVID-19 infection and is further evidence of the important role that platelets play when COVID-19 manifests with thrombotic complications or respiratory failure.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thrombosis / Blood Platelets / COVID-19 Topics: Long Covid Limits: Aged / Humans / Middle aged Language: English Journal: J Clin Pathol Year: 2021 Document Type: Article Affiliation country: Jclinpath-2020-206933

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thrombosis / Blood Platelets / COVID-19 Topics: Long Covid Limits: Aged / Humans / Middle aged Language: English Journal: J Clin Pathol Year: 2021 Document Type: Article Affiliation country: Jclinpath-2020-206933