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The association of ABO blood group with indices of disease severity and multiorgan dysfunction in COVID-19.
Hoiland, Ryan L; Fergusson, Nicholas A; Mitra, Anish R; Griesdale, Donald E G; Devine, Dana V; Stukas, Sophie; Cooper, Jennifer; Thiara, Sonny; Foster, Denise; Chen, Luke Y C; Lee, Agnes Y Y; Conway, Edward M; Wellington, Cheryl L; Sekhon, Mypinder S.
  • Hoiland RL; Department of Anesthesiology, Pharmacology, and Therapeutics, University of British Columbia, Vancouver, BC, Canada.
  • Fergusson NA; Centre for Heart, Lung, and Vascular Health, School of Health and Exercise Sciences, University of British Columbia-Okanagan, Kelowna, BC, Canada.
  • Mitra AR; MD Undergraduate Program, University of British Columbia, Vancouver, BC, Canada.
  • Griesdale DEG; Medicine, Quality, and Safety, Vancouver Coastal Health, Vancouver, BC, Canada.
  • Devine DV; Division of Critical Care Medicine, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
  • Stukas S; Department of Anesthesiology, Pharmacology, and Therapeutics, University of British Columbia, Vancouver, BC, Canada.
  • Cooper J; Medicine, Quality, and Safety, Vancouver Coastal Health, Vancouver, BC, Canada.
  • Thiara S; Division of Critical Care Medicine, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
  • Foster D; Center for Clinical Epidemiology and Evaluation, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada.
  • Chen LYC; Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
  • Lee AYY; Canadian Blood Services, Ottawa, ON, Canada; and.
  • Conway EM; Centre for Blood Research, Life Sciences Institute.
  • Wellington CL; Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
  • Sekhon MS; Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
Blood Adv ; 4(20): 4981-4989, 2020 10 27.
Article in English | MEDLINE | ID: covidwho-873909
ABSTRACT
Studies on severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1) suggest a protective effect of anti-A antibodies against viral cell entry that may hold relevance for SARS-CoV-2 infection. Therefore, we aimed to determine whether ABO blood groups are associated with different severities of COVID-19. We conducted a multicenter retrospective analysis and nested prospective observational substudy of critically ill patients with COVID-19. We collected data pertaining to age, sex, comorbidities, dates of symptom onset, hospital admission, intensive care unit (ICU) admission, mechanical ventilation, continuous renal replacement therapy (CRRT), standard laboratory parameters, and serum inflammatory cytokines. National (N = 398 671; P = .38) and provincial (n = 62 246; P = .60) ABO blood group distributions did not differ from our cohort (n = 95). A higher proportion of COVID-19 patients with blood group A or AB required mechanical ventilation (P = .02) and CRRT (P = .004) and had a longer ICU stay (P = .03) compared with patients with blood group O or B. Blood group A or AB also had an increased probability of requiring mechanical ventilation and CRRT after adjusting for age, sex, and presence of ≥1 comorbidity. Inflammatory cytokines did not differ between patients with blood group A or AB (n = 11) vs O or B (n = 14; P > .10 for all cytokines). Collectively, our data indicate that critically ill COVID-19 patients with blood group A or AB are at increased risk for requiring mechanical ventilation, CRRT, and prolonged ICU admission compared with patients with blood group O or B. Further work is needed to understand the underlying mechanisms.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / ABO Blood-Group System / Coronavirus Infections / Betacoronavirus Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Blood Adv Year: 2020 Document Type: Article Affiliation country: Bloodadvances.2020002623

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / ABO Blood-Group System / Coronavirus Infections / Betacoronavirus Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Blood Adv Year: 2020 Document Type: Article Affiliation country: Bloodadvances.2020002623