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Compare the epidemiological and clinical features of imported and local COVID-19 cases in Hainan, China.
Wu, Biao; Lei, Zi-Ying; Wu, Kun-Liang; He, Jian-Rong; Cao, Hui-Juan; Fu, Juan; Chen, Feng; Chen, Yuan; Chen, Bao; Zhou, Xiao-Li; Huang, Tao; Wu, Tao; Du, Yong-Guo; Chen, Suo-Xian; Xiao, Fu-Rong; Gao, Zhi-Liang; He, Jing; Lin, Feng; Lin, Bing-Liang.
  • Wu B; Department of Infectious Diseases, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, China.
  • Lei ZY; Office of Diseases Control and Prevention, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, China.
  • Wu KL; Department of Infectious Diseases, the Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Road, Guangzhou, China.
  • He JR; GuangDong Provincial Key Laboratory of Liver Diseases, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
  • Cao HJ; Department of Infectious Diseases, The Second Affiliated Hospital of Hainan Medical University, Haikou, China.
  • Fu J; Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, UK.
  • Chen F; Department of Infectious Diseases, the Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Road, Guangzhou, China.
  • Chen Y; GuangDong Provincial Key Laboratory of Liver Diseases, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
  • Chen B; Department of Infectious Diseases, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, China.
  • Zhou XL; Radiology Department, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, China.
  • Huang T; Office of Diseases Control and Prevention, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, China.
  • Wu T; Office of Diseases Control and Prevention, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, China.
  • Du YG; Office of Diseases Control and Prevention, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, China.
  • Chen SX; Clinical laboratory, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, China.
  • Xiao FR; Department of Infectious Diseases, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, China.
  • Gao ZL; Department of Infectious Diseases, The Second Affiliated Hospital of Hainan Medical University, Haikou, China.
  • He J; Department of Infectious Diseases, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, China.
  • Lin F; Department of Infectious Diseases, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, China.
  • Lin BL; Department of Infectious Diseases, the Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Road, Guangzhou, China.
Infect Dis Poverty ; 9(1): 143, 2020 Oct 19.
Article in English | MEDLINE | ID: covidwho-874089
ABSTRACT

BACKGROUND:

Effective management of imported cases is an important part of epidemic prevention and control. Hainan Province, China reported 168 coronavirus disease 2019 (COVID-19), including 112 imported cases on February 19, 2020, but successfully contained the epidemic within 1 month. We described the epidemiological and clinical characteristics of COVID-19 in Hainan and compared these features between imported and local cases to provide information for other international epidemic areas.

METHODS:

We included 91 patients (56 imported and 35 local cases) from two designated hospitals for COVID-19 in Haikou, China, from January 20 to February 19, 2020. Data on the demographic, epidemiological, clinical and laboratory characteristics were extracted from medical records. Patients were followed until April 21, 2020, and the levels of antibodies at the follow-ups were also analysed by the Wilcoxon matched-pairs signed ranks test.

RESULTS:

Of the 91 patients, 78 (85.7%) patients were diagnosed within the first three weeks after the first case was identified (Day 1 Jan 22, 2020), while the number of local cases started to increase during the third week. No new cases occurred after Day 29. Fever and cough were two main clinical manifestations. In total, 15 (16.5%) patients were severe, 14 (15.4%) had complicated infections, nine (9.9%) were admitted to the intensive care unit, and three died. The median duration of viral shedding in feces was longer than that in nasopharyngeal swabs (19 days vs 16 days, P = 0.007). Compared with local cases, imported cases were older and had a higher incidence of fever and concurrent infections. There was no difference in outcomes between the two groups. IgG was positive in 92.8% patients (77/83) in the follow-up at week 2 after discharge, while 88.4% patients (38/43) had a reduction in IgG levels in the follow-up at week 4 after discharge, and the median level was lower than that in the follow-up at week 2 (10.95 S/Cut Off (S/CO) vs 15.02 S/CO, P <  0.001).

CONCLUSION:

Imported cases were more severe than local cases but had similar prognoses. The level of IgG antibodies declined from week 6 to week 8 after onset. The short epidemic period in Hainan suggests that the epidemic could be quickly brought under control if proper timely measures were taken.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Communicable Diseases, Imported Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: Infect Dis Poverty Year: 2020 Document Type: Article Affiliation country: S40249-020-00755-7

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Communicable Diseases, Imported Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: Infect Dis Poverty Year: 2020 Document Type: Article Affiliation country: S40249-020-00755-7