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Convalescent Plasma: The Relay Baton in the Race for Coronavirus Disease 2019 Treatment.
Ouyang, Jing; Isnard, Stéphane; Lin, John; Fombuena, Brandon; Peng, Xiaorong; Routy, Jean-Pierre; Chen, Yaokai.
  • Ouyang J; Infectious Diseases and Immunity in Global Health Program, Research Institute, McGill University Health Centre, Montréal, QC, Canada.
  • Isnard S; Chronic Viral Illness Service, McGill University Health Centre, Montréal, QC, Canada.
  • Lin J; Chongqing Public Health Medical Center, Chongqing, China.
  • Fombuena B; Infectious Diseases and Immunity in Global Health Program, Research Institute, McGill University Health Centre, Montréal, QC, Canada.
  • Peng X; Chronic Viral Illness Service, McGill University Health Centre, Montréal, QC, Canada.
  • Routy JP; Infectious Diseases and Immunity in Global Health Program, Research Institute, McGill University Health Centre, Montréal, QC, Canada.
  • Chen Y; Chronic Viral Illness Service, McGill University Health Centre, Montréal, QC, Canada.
Front Immunol ; 11: 570063, 2020.
Article in English | MEDLINE | ID: covidwho-874478
ABSTRACT
Coronavirus disease 2019 (COVID-19) is a pandemic caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Most infected people have mild or moderate symptoms and recover without the need for extensive treatment. However, for seriously ill patients, no specific treatments are currently available. Convalescent plasma therapy (CPT), a passive immunotherapy, involves infusing plasma from recovered people into actively infected people, and is thought to be a specific intervention to improve outcome in patients with severe COVID-19. The presumed mechanism involves neutralizing antibodies and antibody dependent cytotoxicity/phagocytosis. Previous CPT trials showed an effect in SARS and pilot studies suggest CPT is an effective and safe strategy for seriously ill COVID-19 patients. CPT is currently being tested in large randomized clinical trials. Herein, we critically review the mechanism, applications and the challenges for CPT in the treatment of severe COVID-19, paving the way toward vaccine and immunotherapy development.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Antibodies, Neutralizing / Pandemics / Betacoronavirus / Antibodies, Viral Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Humans Language: English Journal: Front Immunol Year: 2020 Document Type: Article Affiliation country: Fimmu.2020.570063

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Antibodies, Neutralizing / Pandemics / Betacoronavirus / Antibodies, Viral Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Humans Language: English Journal: Front Immunol Year: 2020 Document Type: Article Affiliation country: Fimmu.2020.570063