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Comprehensive analysis of two potential novel SARS-CoV-2 entries, TMPRSS2 and IFITM3, in healthy individuals and cancer patients.
Dai, Yu-Jun; Zhang, Wei-Na; Wang, Wei-Da; He, Si-Yuan; Liang, Cheng-Cai; Wang, Da-Wei.
  • Dai YJ; Collaborative Innovation Center for Cancer Medicine, 651 Dongfeng East Road, Guangzhou, 510060, China.
  • Zhang WN; State Key Laboratory of Oncology in South China, Guangzhou, 510060, China.
  • Wang WD; Department of Hematologic Oncology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China.
  • He SY; Department of Hematology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510623, China.
  • Liang CC; Collaborative Innovation Center for Cancer Medicine, 651 Dongfeng East Road, Guangzhou, 510060, China.
  • Wang DW; State Key Laboratory of Oncology in South China, Guangzhou, 510060, China.
Int J Biol Sci ; 16(15): 3028-3036, 2020.
Article in English | MEDLINE | ID: covidwho-874840
ABSTRACT
Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2, with acute respiratory failure as the most significant symptom, has led to a global pandemic. Angiotensin-converting enzyme 2 (ACE2) is considered as the most important receptor of SARS-CoV-2 and wildly expressed in human tissues. Whereas, the extremely low expression of ACE2 in lung could hardly interpret the severe symptom of pneumonia in COVID-19 patients. Here we profiled two SARS-CoV-2 infection related genes, the transmembrane serine protease 2 (TMPRSS2) and the interferon-inducible transmembrane protein 3 (IFITM3), in human tissues and organs. Consistent with the expression and distribution of ACE2, TMPRSS2 was also highly expressed in digestive, urinary and reproductive systems, but low expressed in lung. Notably, the anti-virus protein IFITM3 also expressed much lower in lung than other tissues, which might be related to the severe lung symptoms of COVID-19. In addition, the low expression of IFITM3 in immune cells suggested that SARS-CoV-2 might attack lymphocytes and induce the cytokine release syndrome (CRS). Furthermore, cancer patients were considered as more susceptible to SARS-CoV-2 infection. Our data supposed that fourteen types of tumors might have different susceptibility to the virus according to ACE2, TMPRSS2 and IFITM3 expression patterns. Interestingly the prognosis of six types of cancers including breast carcinoma (BRCA), lung adenocarcinoma (LUAD), uterine corpus endometrial carcinoma (UCEC), renal clear cell carcinoma (KIRC), prostate adenocarcinoma (PRAD), and hepatocellular carcinoma (LIHC) were closely related to these gene expressions. Our study explored the expression and distribution profiles of two potential novel molecules that might participate in SARS-CoV-2 infection and involved in immunity, which may provide a functional basis for preventing infection of SARS-CoV-2.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Receptors, Virus / Serine Endopeptidases / Gene Expression Regulation, Neoplastic / RNA-Binding Proteins / Membrane Proteins / Neoplasms Type of study: Diagnostic study / Prognostic study Limits: Humans Language: English Journal: Int J Biol Sci Journal subject: Biology Year: 2020 Document Type: Article Affiliation country: Ijbs.51234

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Receptors, Virus / Serine Endopeptidases / Gene Expression Regulation, Neoplastic / RNA-Binding Proteins / Membrane Proteins / Neoplasms Type of study: Diagnostic study / Prognostic study Limits: Humans Language: English Journal: Int J Biol Sci Journal subject: Biology Year: 2020 Document Type: Article Affiliation country: Ijbs.51234