A Real-World Evidence Framework for Optimizing Dosing in All Patients With COVID-19.

Peck, Richard W; Weiner, Daniel; Cook, Jack; Robert Powell, J

Peck, Richard W; Weiner, Daniel; Cook, Jack; Robert Powell, J.

Peck RW; Clinical Pharmacology, Pharma Research & Early Development, Roche Innovation Center, Basel, Switzerland.
Weiner D; Pharmacometrics Consultant, Chapel Hill, North Carolina, USA.
Cook J; Clinical Pharmacology, Pfizer Inc, Groton, Connecticut, USA.
Robert Powell J; Clinical Pharmacology Consultant, Chapel Hill, North Carolina, USA.

Clin Pharmacol Ther ; 108(5): 921-923, 2020 11.

Article in English | MEDLINE | ID: covidwho-878708

ABSTRACT

ABSTRACT

Potential treatments for coronavirus disease 2019 (COVID-19) are being investigated at unprecedented speed, and successful treatments will rapidly be used in tens or hundreds of thousands of patients. To ensure safe and effective use in all those patents it is essential also to develop, at unprecedented speed, a means to provide frequently updated, optimal dosing information for all patient subgroups. Success will require immediate collaboration between drug developers, academics, and regulators.

Subject(s)

Antiviral Agents; Coronavirus Infections; Dose-Response Relationship, Drug; Drug Development; Drug Repositioning; Drug-Related Side Effects and Adverse Reactions; Pandemics; Pneumonia, Viral; Antiviral Agents/pharmacokinetics; Antiviral Agents/therapeutic use; Betacoronavirus/drug effects; Biological Availability; Biomarkers, Pharmacological/analysis; COVID-19; Coronavirus Infections/drug therapy; Coronavirus Infections/epidemiology; Drug Development/methods; Drug Development/standards; Drug Dosage Calculations; Drug Monitoring/standards; Drug Repositioning/methods; Drug Repositioning/standards; Drug-Related Side Effects and Adverse Reactions/blood; Drug-Related Side Effects and Adverse Reactions/prevention & control; Humans; International Cooperation; Pneumonia, Viral/drug therapy; Pneumonia, Viral/epidemiology; SARS-CoV-2; Treatment Outcome

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Pneumonia, Viral / Coronavirus Infections / Dose-Response Relationship, Drug / Drug-Related Side Effects and Adverse Reactions / Drug Repositioning / Pandemics / Drug Development Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: Clin Pharmacol Ther Year: 2020 Document Type: Article Affiliation country: Cpt.1922

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