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Cell-mediated and humoral adaptive immune responses to SARS-CoV-2 are lower in asymptomatic than symptomatic COVID-19 patients.
Mazzoni, Alessio; Maggi, Laura; Capone, Manuela; Spinicci, Michele; Salvati, Lorenzo; Colao, Maria Grazia; Vanni, Anna; Kiros, Seble Tekle; Mencarini, Jessica; Zammarchi, Lorenzo; Mantengoli, Elisabetta; Menicacci, Lorenzo; Caldini, Eleonora; Romagnani, Sergio; Liotta, Francesco; Morettini, Alessandro; Rossolini, Gian Maria; Bartoloni, Alessandro; Cosmi, Lorenzo; Annunziato, Francesco.
  • Mazzoni A; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
  • Maggi L; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
  • Capone M; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
  • Spinicci M; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
  • Salvati L; Infectious and Tropical Diseases Unit, Careggi University Hospital, Florence, Italy.
  • Colao MG; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
  • Vanni A; Microbiology and Virology Unit, Careggi University Hospital, Florence, Italy.
  • Kiros ST; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
  • Mencarini J; Microbiology and Virology Unit, Careggi University Hospital, Florence, Italy.
  • Zammarchi L; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
  • Mantengoli E; Infectious and Tropical Diseases Unit, Careggi University Hospital, Florence, Italy.
  • Menicacci L; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
  • Caldini E; Infectious and Tropical Diseases Unit, Careggi University Hospital, Florence, Italy.
  • Romagnani S; Infectious and Tropical Diseases Unit, Careggi University Hospital, Florence, Italy.
  • Liotta F; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
  • Morettini A; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
  • Rossolini GM; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
  • Bartoloni A; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
  • Cosmi L; Immunology and Cell Therapy Unit, Careggi University Hospital, Florence, Italy.
  • Annunziato F; Internal Medicine 2 Unit, Careggi University Hospital, Florence, Italy.
Eur J Immunol ; 50(12): 2013-2024, 2020 Dec.
Article in English | MEDLINE | ID: covidwho-880266
ABSTRACT
The characterization of cell-mediated and humoral adaptive immune responses to SARS-CoV-2 is fundamental to understand COVID-19 progression and the development of immunological memory to the virus. In this study, we detected T-cells reactive to SARS-CoV-2 proteins M, S, and N, as well as serum virus-specific IgM, IgA, IgG, in nearly all SARS-CoV-2 infected individuals, but not in healthy donors. Virus-reactive T cells exhibited signs of in vivo activation, as suggested by the surface expression of immune-checkpoint molecules PD1 and TIGIT. Of note, we detected antigen-specific adaptive immune response both in asymptomatic and symptomatic SARS-CoV-2 infected subjects. More importantly, symptomatic patients displayed a significantly higher magnitude of both cell-mediated and humoral adaptive immune response to the virus, as compared to asymptomatic individuals. These findings suggest that an uncontrolled adaptive immune response contribute to the development of the life-threatening inflammatory phase of the disease. Finally, this study might open the way to develop effective vaccination strategies.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: T-Lymphocytes / Carrier State / Immunity, Humoral / SARS-CoV-2 / COVID-19 / Antibodies, Viral Topics: Vaccines Limits: Adult / Female / Humans Language: English Journal: Eur J Immunol Year: 2020 Document Type: Article Affiliation country: Eji.202048915

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Full text: Available Collection: International databases Database: MEDLINE Main subject: T-Lymphocytes / Carrier State / Immunity, Humoral / SARS-CoV-2 / COVID-19 / Antibodies, Viral Topics: Vaccines Limits: Adult / Female / Humans Language: English Journal: Eur J Immunol Year: 2020 Document Type: Article Affiliation country: Eji.202048915