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Evaluation of three immunochromatographic tests in COVID-19 serologic diagnosis and their clinical usefulness.
Pegoraro, Manuela; Militello, Valentina; Salvagno, Gian Luca; Gaino, Stefania; Bassi, Antonella; Caloi, Cecilia; Peretti, Angelo; Bizzego, Silvia; Poletto, Laura; Bovo, Chiara; Lippi, Giuseppe; Lo Cascio, Giuliana.
  • Pegoraro M; Microbiology and Virology Unit, Department of Pathology, Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy. manuela.pegoraro@aovr.veneto.it.
  • Militello V; Microbiology and Virology Unit, Department of Pathology, Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy.
  • Salvagno GL; Section of Clinical Biochemistry, University of Verona, Verona, Italy.
  • Gaino S; Section of Clinical Biochemistry, University of Verona, Verona, Italy.
  • Bassi A; Section of Clinical Biochemistry, University of Verona, Verona, Italy.
  • Caloi C; Microbiology and Virology Unit, Department of Pathology, Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy.
  • Peretti A; Microbiology and Virology Unit, Department of Pathology, Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy.
  • Bizzego S; Microbiology and Virology Unit, Department of Pathology, Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy.
  • Poletto L; Microbiology and Virology Unit, Department of Pathology, Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy.
  • Bovo C; Medical Direction, University Hospital of Verona, Verona, Italy.
  • Lippi G; Section of Clinical Biochemistry, University of Verona, Verona, Italy.
  • Lo Cascio G; Microbiology and Virology Unit, Department of Pathology, Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy.
Eur J Clin Microbiol Infect Dis ; 40(4): 897-900, 2021 Apr.
Article in English | MEDLINE | ID: covidwho-880322
ABSTRACT
Results of three rapid immunochromatographic tests (ICTs) were compared with those obtained with two automated immunoassays for evaluation of their usefulness. One hundred fifty-nine patients and 67 healthy volunteers were included. Different assays demonstrate 41-45% of diagnostic sensitivities and 91-98% of specificities, with substantial agreement (89.3-91.2%), but a high percentage of weak positive results (13-22%) was observed with ICTs. ICTs performances were comparable to those of automated immunoassays. ICTs could have a role as screening approach due to their easy usability. Subjective interpretation, significant rate of uncertain results, uncertainty on viral antigens source are undoubtedly drawbacks.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunoassay / Spike Glycoprotein, Coronavirus / Coronavirus Nucleocapsid Proteins / COVID-19 Serological Testing / COVID-19 / Antibodies, Viral Type of study: Diagnostic study / Experimental Studies / Prognostic study Limits: Adolescent / Adult / Aged / Child / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Eur J Clin Microbiol Infect Dis Journal subject: Communicable Diseases / Microbiology Year: 2021 Document Type: Article Affiliation country: S10096-020-04040-1

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunoassay / Spike Glycoprotein, Coronavirus / Coronavirus Nucleocapsid Proteins / COVID-19 Serological Testing / COVID-19 / Antibodies, Viral Type of study: Diagnostic study / Experimental Studies / Prognostic study Limits: Adolescent / Adult / Aged / Child / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Eur J Clin Microbiol Infect Dis Journal subject: Communicable Diseases / Microbiology Year: 2021 Document Type: Article Affiliation country: S10096-020-04040-1