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[Metformin: one of the possible options to reduce the mortality of severe coronavirus disease 2019?]
Pan, Yonghong; Han, Rui; He, Yong.
  • Pan Y; Department of Pulmonary and Critical Care Medicine, Daping Hospital, Army Medical University, Chongqing 400042, China. Corresponding author: He Yong, Email: heyong8998@126.com.
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue ; 32(9): 1131-1134, 2020 Sep.
Article in Chinese | MEDLINE | ID: covidwho-883891
ABSTRACT
According to the world epidemic report, the mortality of patients with severe coronavirus disease 2019 (COVID-19) is high. Diabetic patients are more susceptible to COVID-19. Since the mortality of COVID-19 patients with diabetes is on the top of list, hyperglycemia is considered an independent risk factor for severe COVID-19. Up to now, there is few effective treatment for severe patients infected with 2019 novel coronavirus (2019-nCoV). Clinical studies observed that cytokine storms existed in patients with severe COVID-19. Sustained high levels of cytokines cause diffuse damage to pulmonary capillary endothelial cells and alveolar epithelial cells, resulting in acute respiratory distress syndrome (ARDS). ARDS is the main cause of death in COVID-19 patients. Host-directed therapy (HDT) is an emerging therapeutic method in the field of anti-infection, which can activate the self-protective immune response, suppress excessive inflammatory response, and be used to assist the treatment of traditional drugs to shorten the course of disease. Metformin has been shown to be effective in HDT and can assist in the treatment of the viral and bacterial infectious disease. This paper discusses the rationality and potential therapeutic mechanism of metformin in the treatment of severe COVID-19. It was speculated that the use of metformin for controlling blood glucose in severe COVID-19 patients with diabetes may prevent or inhibit the occurrence of ARDS, thereby reducing the mortality of COVID-19 patients. The possible mechanism is that metformin could inhibit cytokine storm via suppressing interleukin-6 (IL-6) signaling, prevent the process of lung fibrosis, suppress endocytosis, thereby elevating angiotensin converting enzyme 2 (ACE2) expression.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Pandemics / Betacoronavirus / Metformin Type of study: Prognostic study Language: Chinese Journal: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Pandemics / Betacoronavirus / Metformin Type of study: Prognostic study Language: Chinese Journal: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue Year: 2020 Document Type: Article