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The phenotypic changes of γδ T cells in COVID-19 patients.
Lei, Lei; Qian, Hongbo; Yang, Xiaofang; Zhang, Xingzhe; Zhang, Dan; Dai, Tongxin; Guo, Rui; Shi, Lin; Cheng, Yanbin; Zhang, Baojun; Zhou, Xiaobo; Hu, Jinsong; Guo, Yaling.
  • Lei L; Department of Pathogenic Microbiology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, China.
  • Qian H; Department of Clinical Laboratory, The 8th hospital of Xi'an, Xi'an, China.
  • Yang X; Department of Pathogenic Microbiology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, China.
  • Zhang X; Department of Pathogenic Microbiology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, China.
  • Zhang D; Department of Pathogenic Microbiology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, China.
  • Dai T; Department of Clinical Laboratory, The 8th hospital of Xi'an, Xi'an, China.
  • Guo R; Department of Clinical Laboratory, The 8th hospital of Xi'an, Xi'an, China.
  • Shi L; Department of Pathogenic Microbiology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, China.
  • Cheng Y; Department of Pathogenic Microbiology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, China.
  • Zhang B; Department of Pathogenic Microbiology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, China.
  • Zhou X; Department of Pathogenic Microbiology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, China.
  • Hu J; Key Laboratory of Environment and Genes Related to Diseases, Xi'an Jiaotong University Health Science Center, Xi'an, China.
  • Guo Y; Institute of Infection and Immunity, Translational Medicine Institute, Xi'an Jiaotong University Health Science Center, Xi'an, China.
J Cell Mol Med ; 24(19): 11603-11606, 2020 10.
Article in English | MEDLINE | ID: covidwho-884888
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ABSTRACT
A novel pneumonia-associated respiratory syndrome named coronavirus disease-2019 (COVID-19), which was caused by SARS-CoV-2，broke out in Wuhan, China, in the end of 2019. Unfortunately, there is no specific antiviral agent or vaccine available to treat SARS-CoV-2 infections. The information regarding the immunological characteristics in COVID-19 patients remains limited. Here, we collected the blood samples from 18 healthy donors (HD) and 38 COVID-19 patients to analyze changes on γδ T cell population. In comparison with HD, the γδ T cell percentage decreased, while the activation marker CD25 expression increased in response to SARS-CoV-2 infection. Interestingly, the CD4 expression was upregulated in γδ T cells reflecting the occurrence of a specific effector cell population, which may serve as a biomarker for the assessment of SARS-CoV-2 infection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / T-Lymphocyte Subsets / Coronavirus Infections Type of study: Prognostic study Topics: Vaccines / Variants Limits: Adult / Humans Country/Region as subject: Asia Language: English Journal: J Cell Mol Med Journal subject: Molecular Biology Year: 2020 Document Type: Article Affiliation country: Jcmm.15620

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / T-Lymphocyte Subsets / Coronavirus Infections Type of study: Prognostic study Topics: Vaccines / Variants Limits: Adult / Humans Country/Region as subject: Asia Language: English Journal: J Cell Mol Med Journal subject: Molecular Biology Year: 2020 Document Type: Article Affiliation country: Jcmm.15620