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Innate and adaptive immune responses against coronavirus.
Hosseini, Arezoo; Hashemi, Vida; Shomali, Navid; Asghari, Faezeh; Gharibi, Tohid; Akbari, Morteza; Gholizadeh, Saber; Jafari, Abbas.
  • Hosseini A; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Hashemi V; Department of Basic Science, Faculty of Medicine, Maragheh University of Medical Sciences, Maragheh, Iran.
  • Shomali N; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Asghari F; Department of Immunology, School of Medicine, Tarbiat Modares University of Medical Sciences, Tehran, Iran.
  • Gharibi T; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Akbari M; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Gholizadeh S; Department of Medical Entomology and Vector Control, School of Public Health, Urmia University of Medical Sciences, Urmia, Iran.
  • Jafari A; Department of Toxicology and Cellular and Molecular Research Center, School of Public Health, Urmia University of Medical Sciences, Urmia, Iran. Electronic address: jafari.ab@umsu.ac.ir.
Biomed Pharmacother ; 132: 110859, 2020 Dec.
Article in English | MEDLINE | ID: covidwho-885208
ABSTRACT
Coronaviruses (CoVs) are a member of the Coronaviridae family with positive-sense single- stranded RNA. In recent years, the CoVs have become a global problem to public health. The immune responses (innate and adaptive immunity) are essential for elimination and clearance of CoVs infections, however, uncontrolled immune responses can result in aggravating acute lung injury and significant immunopathology. Gaining profound understanding about the interaction between CoVs and the innate and adaptive immune systems could be a critical step in the field of treatment. In this review, we present an update on the host innate and adaptive immune responses against SARS-CoV, MERS-CoV and newly appeared SARS-CoV-2.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Adaptive Immunity / SARS-CoV-2 / COVID-19 / Immunity, Innate Limits: Animals / Humans Language: English Journal: Biomed Pharmacother Year: 2020 Document Type: Article Affiliation country: J.biopha.2020.110859

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Adaptive Immunity / SARS-CoV-2 / COVID-19 / Immunity, Innate Limits: Animals / Humans Language: English Journal: Biomed Pharmacother Year: 2020 Document Type: Article Affiliation country: J.biopha.2020.110859