Therapeutic potential for clomiphene, a selective estrogen receptor modulator, in the treatment of COVID-19.

Ghasemnejad-Berenji, Morteza; Pashapour, Sarvin; Ghasemnejad-Berenji, Hojat

Ghasemnejad-Berenji, Morteza; Pashapour, Sarvin; Ghasemnejad-Berenji, Hojat.

Ghasemnejad-Berenji M; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran. Electronic address: mghasemnejad@alumnus.tums.ac.ir.
Pashapour S; Department of Pediatrics, Faculty of Medicine, Motahari Hospital, Urmia University of Medical Sciences, Urmia, Iran.
Ghasemnejad-Berenji H; Department of Anatomy and Reproductive Biology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Med Hypotheses ; 145: 110354, 2020 12.

Article in English | MEDLINE | ID: covidwho-885392

Subject(s)

Antiviral Agents/therapeutic use; COVID-19 Drug Treatment; Clomiphene/therapeutic use; SARS-CoV-2/drug effects; Selective Estrogen Receptor Modulators/therapeutic use; Virus Internalization/drug effects; Antiviral Agents/pharmacology; COVID-19/epidemiology; Clomiphene/pharmacology; Drug Repositioning; Ebolavirus/drug effects; Endosomes/drug effects; Humans; Intracellular Signaling Peptides and Proteins/antagonists & inhibitors; Lysosomes/drug effects; Models, Biological; Niemann-Pick C1 Protein; Pandemics; SARS-CoV-2/physiology; Selective Estrogen Receptor Modulators/pharmacology

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Clomiphene / Selective Estrogen Receptor Modulators / Virus Internalization / SARS-CoV-2 / COVID-19 Drug Treatment Type of study: Observational study Limits: Humans Language: English Journal: Med Hypotheses Year: 2020 Document Type: Article

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