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Presenting Characteristics, Treatment Patterns, and Outcomes among Patients with Venous Thromboembolism during Hospitalization for COVID-19.
Fernández-Capitán, Carmen; Barba, Raquel; Díaz-Pedroche, María Del Carmen; Sigüenza, Patricia; Demelo-Rodriguez, Pablo; Siniscalchi, Carmine; Pedrajas, José María; Farfán-Sedano, Ana I; Olivera, Pavel Eduardo; Gómez-Cuervo, Covadonga; Llamas, Pilar; Villares, Paula; Sanchez, Olivier; López-Reyes, Raquel; Catella, Judith; Bikdeli, Behnood; Weinberg, Ido; Tafur, Alfonso J; Jiménez, David; Monreal, Manuel.
  • Fernández-Capitán C; Department of Internal Medicine, Hospital Universitario La Paz, Madrid, Spain.
  • Barba R; Department of Internal Medicine, Hospital Rey Juan Carlos, Madrid, Spain.
  • Díaz-Pedroche MDC; Department of Internal Medicine, Hospital Universitario 12 de Octubre, Madrid, Spain.
  • Sigüenza P; Department of Internal Medicine, Hospital Germans Trias I Pujol, Badalona, Barcelona, Spain.
  • Demelo-Rodriguez P; Department of Internal Medicine, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
  • Siniscalchi C; Department of Internal and Emergency Medicine, Angiology Unit, Parma University Hospital, Parma, Italy.
  • Pedrajas JM; Department of Internal Medicine, Hospital Clínico San Carlos, Madrid, Spain.
  • Farfán-Sedano AI; Department of Internal Medicine, Hospital Universitario de Fuenlabrada, Madrid, Spain.
  • Olivera PE; Department of Hematology, Hospital Universitari Sagrat Cor, Barcelona, Spain.
  • Gómez-Cuervo C; Department of Internal Medicine, Hospital Universitario 12 de Octubre, Madrid, Spain.
  • Llamas P; Department of Hematology, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain.
  • Villares P; Department of Internal Medicine, Hospital de Madrid Norte Sanchinarro. Madrid, Spain.
  • Sanchez O; Department of Pneumonology, Hôpital Europeen Georges Pompidou, Paris, France.
  • López-Reyes R; Department of Pneumonology, Hospital Universitari i Politècnic La Fe, Valencia, Spain.
  • Catella J; Department of Internal Medicine, Hôpital Édouard Herriot, Lyon, France.
  • Bikdeli B; Department of Cardiology, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
  • Weinberg I; Department of Cardiology, Yale/YNHH Center for Outcomes Research & Evaluation, New Haven, Connecticut.
  • Tafur AJ; Department of Cardiology, Cardiovascular Research Foundation, New York, New York.
  • Jiménez D; Department of Cardiology, Massachusetts General Hospital, Boston, Massachusetts.
  • Monreal M; Department of Medicine and Vascular Medicine, Evanston NorthShore University Health System, Evanston, Illinois.
Semin Thromb Hemost ; 47(4): 351-361, 2021 Jun.
Article in English | MEDLINE | ID: covidwho-885548
ABSTRACT
Venous thromboembolism (VTE) is common in patients with coronavirus disease-2019 (COVID-19). However, limited data exist on patient characteristics, treatments, and outcomes. To describe the clinical characteristics, treatment patterns, and short-term outcomes of patients diagnosed with VTE during hospitalization for COVID-19. This is a prospective multinational study of patients with incident VTE during the course of hospitalization for COVID-19. Data were obtained from the Registro Informatizado de la Enfermedad TromboEmbólica (RIETE) registry. All-cause mortality, VTE recurrences, and major bleeding during the first 10 days were separately investigated for patients in hospital wards versus those in intensive care units (ICUs). As of May 03, 2020, a total number of 455 patients were diagnosed with VTE (83% pulmonary embolism, 17% isolated deep vein thrombosis) during their hospital stay; 71% were male, the median age was 65 (interquartile range, 55-74) years. Most patients (68%) were hospitalized in medical wards, and 145 in ICUs. Three hundred and seventeen (88%; 95% confidence interval [CI] 84-91%) patients were receiving thromboprophylaxis at the time of VTE diagnosis. Most patients (88%) received therapeutic low-molecular-weight heparin, and 15 (3.6%) received reperfusion therapies. Among 420 patients with complete 10-day follow-up, 51 (12%; 95% CI 9.3-15%) died, no patient recurred, and 12 (2.9%; 95% CI 1.6-4.8%) experienced major bleeding. The 10-day mortality rate was 9.1% (95% CI 6.1-13%) among patients in hospital wards and 19% (95% CI 13-26%) among those in ICUs. This study provides characteristics and early outcomes of patients diagnosed with acute VTE during hospitalization for COVID-19. Additional studies are needed to identify the optimal strategies to prevent VTE and to mitigate adverse outcomes associated.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Registries / Hospital Mortality / Heparin, Low-Molecular-Weight / Venous Thromboembolism / COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Semin Thromb Hemost Year: 2021 Document Type: Article Affiliation country: S-0040-1718402

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Registries / Hospital Mortality / Heparin, Low-Molecular-Weight / Venous Thromboembolism / COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Semin Thromb Hemost Year: 2021 Document Type: Article Affiliation country: S-0040-1718402