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Clinical characteristics of 116 hospitalized patients with COVID-19 in Wuhan, China: a single-centered, retrospective, observational study.
Xiong, Shiqiang; Liu, Lin; Lin, Feng; Shi, Jinhu; Han, Lei; Liu, Huijian; He, Lewei; Jiang, Qijun; Wang, Zeyang; Fu, Wenbo; Li, Zhigang; Lu, Qing; Chen, Zhinan; Ding, Shifang.
  • Xiong S; Department of Cardiology, the General Hospital of Central Theater Command, Wuhan, 430000, China.
  • Liu L; Department of Integrated Traditional Chinese and Western Internal Medicine, the General Hospital of Central Theater Command, Wuhan, 430000, China.
  • Lin F; Department of Cardiology, the General Hospital of Central Theater Command, Wuhan, 430000, China.
  • Shi J; Department of Cardiology, the General Hospital of Central Theater Command, Wuhan, 430000, China.
  • Han L; Division of Medical Management, the General Hospital of Central Theater Command, Wuhan, 430000, China.
  • Liu H; Department of Cardiology, the General Hospital of Central Theater Command, Wuhan, 430000, China.
  • He L; Department of Cardiology, the General Hospital of Central Theater Command, Wuhan, 430000, China.
  • Jiang Q; Department of Cardiology, the General Hospital of Central Theater Command, Wuhan, 430000, China.
  • Wang Z; Department of Cardiology, the General Hospital of Central Theater Command, Wuhan, 430000, China.
  • Fu W; Department of Cardiology, the General Hospital of Central Theater Command, Wuhan, 430000, China.
  • Li Z; Department of Cardiology, the General Hospital of Central Theater Command, Wuhan, 430000, China.
  • Lu Q; Department of Cardiology, the General Hospital of Central Theater Command, Wuhan, 430000, China.
  • Chen Z; Department of Cardiology, the General Hospital of Central Theater Command, Wuhan, 430000, China.
  • Ding S; Department of Cardiology, the General Hospital of Central Theater Command, Wuhan, 430000, China. dsfmdwh@163.com.
BMC Infect Dis ; 20(1): 787, 2020 Oct 22.
Article in English | MEDLINE | ID: covidwho-885974
Semantic information from SemMedBD (by NLM)
1. COVID-19 PROCESS_OF hospitalized patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
hospitalized patients
2. 2019 novel coronavirus CAUSES COVID-19
Subject
2019 novel coronavirus
Predicate
CAUSES
Object
COVID-19
3. Cardiovascular Diseases PROCESS_OF Human Age Group
Subject
Cardiovascular Diseases
Predicate
PROCESS_OF
Object
Human Age Group
4. Cardiovascular Diseases PROCESS_OF Middle Aged
Subject
Cardiovascular Diseases
Predicate
PROCESS_OF
Object
Middle Aged
5. Cardiovascular Diseases PROCESS_OF Old age
Subject
Cardiovascular Diseases
Predicate
PROCESS_OF
Object
Old age
6. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
7. Lymphopenia PROCESS_OF Patients
Subject
Lymphopenia
Predicate
PROCESS_OF
Object
Patients
8. Lactate Dehydrogenase Increased PROCESS_OF Patients
Subject
Lactate Dehydrogenase Increased
Predicate
PROCESS_OF
Object
Patients
9. Borg Category-Ratio 10 Perceived Exertion Score 5 PROCESS_OF Patients
Subject
Borg Category-Ratio 10 Perceived Exertion Score 5
Predicate
PROCESS_OF
Object
Patients
10. Hypertensive disease PROCESS_OF Patients
Subject
Hypertensive disease
Predicate
PROCESS_OF
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Patients
11. Cardiovascular LOCATION_OF Comorbidity
Subject
Cardiovascular
Predicate
LOCATION_OF
Object
Comorbidity
12. Structure of median lobe of prostate LOCATION_OF 2019 novel coronavirus
Subject
Structure of median lobe of prostate
Predicate
LOCATION_OF
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2019 novel coronavirus
13. Heart Injuries PROCESS_OF Patients
Subject
Heart Injuries
Predicate
PROCESS_OF
Object
Patients
14. Disease AFFECTS COVID-19
Subject
Disease
Predicate
AFFECTS
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COVID-19
15. COVID-19 PROCESS_OF hospitalized patients
Subject
COVID-19
Predicate
PROCESS_OF
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hospitalized patients
16. 2019 novel coronavirus CAUSES COVID-19
Subject
2019 novel coronavirus
Predicate
CAUSES
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COVID-19
17. Cardiovascular Diseases PROCESS_OF Human Age Group
Subject
Cardiovascular Diseases
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PROCESS_OF
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Human Age Group
18. Cardiovascular Diseases PROCESS_OF Middle Aged
Subject
Cardiovascular Diseases
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PROCESS_OF
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Middle Aged
19. Cardiovascular Diseases PROCESS_OF Old age
Subject
Cardiovascular Diseases
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PROCESS_OF
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Old age
20. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
21. Lymphopenia PROCESS_OF Patients
Subject
Lymphopenia
Predicate
PROCESS_OF
Object
Patients
22. Lactate Dehydrogenase Increased PROCESS_OF Patients
Subject
Lactate Dehydrogenase Increased
Predicate
PROCESS_OF
Object
Patients
23. Borg Category-Ratio 10 Perceived Exertion Score 5 PROCESS_OF Patients
Subject
Borg Category-Ratio 10 Perceived Exertion Score 5
Predicate
PROCESS_OF
Object
Patients
24. Hypertensive disease PROCESS_OF Patients
Subject
Hypertensive disease
Predicate
PROCESS_OF
Object
Patients
25. Cardiovascular LOCATION_OF Comorbidity
Subject
Cardiovascular
Predicate
LOCATION_OF
Object
Comorbidity
26. Structure of median lobe of prostate LOCATION_OF 2019 novel coronavirus
Subject
Structure of median lobe of prostate
Predicate
LOCATION_OF
Object
2019 novel coronavirus
27. Heart Injuries PROCESS_OF Patients
Subject
Heart Injuries
Predicate
PROCESS_OF
Object
Patients
28. Disease AFFECTS COVID-19
Subject
Disease
Predicate
AFFECTS
Object
COVID-19
ABSTRACT

BACKGROUND:

A cluster of acute respiratory illness, now known as Corona Virus Disease 2019 (COVID-19) caused by 2019 novel coronavirus (SARS-CoV-2), has become a global pandemic. Aged population with cardiovascular diseases are more likely be to infected with SARS-CoV-2 and result in more severe outcomes and elevated case-fatality rate. Meanwhile, cardiovascular diseases have a high prevalence in the middle-aged and elderly population. However, despite of several researches in COVID-19, cardiovascular implications related to it still remains largely unclear. Therefore, a specific analysis in regard to cardiovascular implications of COVID-19 patients is in great need.

METHODS:

In this single-centered, retrospective, observational study, 116 patients with laboratory-confirmed COVID-19 were enrolled, who admitted to the General Hospital of Central Theater Command (Wuhan, China) from January 20 to March 8, 2020. The demographic data, underlying comorbidities, clinical symptoms and signs, laboratory findings, chest computed tomography, treatment measures, and outcome data were collected from electronic medical records. Data were compared between non-severe and severe cases.

RESULTS:

Of 116 hospitalized patients with COVID-19, the median age was 58.5 years (IQR, 47.0-69.0), and 36 (31.0%) were female. Hypertension (45 [38.8%]), diabetes (19 [16.4%]), and coronary heart disease (17 [14.7%]) were the most common coexisting conditions. Common symptoms included fever [99 (85.3%)], dry cough (61 [52.6%]), fatigue (60 [51.7%]), dyspnea (52 [44.8%]), anorexia (50 [43.1%]), and chest discomfort (50 [43.1%]). Local and/or bilateral patchy shadowing were the typical radiological findings on chest computed tomography. Lymphopenia (lymphocyte count, 1.0 × 109/L [IQR, 0.7-1.3]) was observed in 66 patients (56.9%), and elevated lactate dehydrogenase (245.5 U/L [IQR, 194.3-319.8]) in 69 patients (59.5%). Hypokalemia occurred in 24 (20.7%) patients. Compared with non-severe cases, severe cases were older (64.0 years [IQR, 53.0-76.0] vs 56.0 years [IQR, 37.0-64.0]), more likely to have comorbidities (35 [63.6%] vs 24 [39.3%]), and more likely to develop acute cardiac injury (19 [34.5%] vs 4 [6.6%]), acute heart failure (18 [32.7%] vs 3 [4.9%]), and ARDS (20 [36.4%] vs 0 [0%]). During hospitalization, the prevalence of new onset hypertension was significantly higher in severe patients (55.2% vs 19.0%) than in non-severe ones.

CONCLUSIONS:

In this single-centered, retrospective, observational study, we found that the infection of SARS-CoV-2 was more likely to occur in middle and aged population with cardiovascular comorbidities. Cardiovascular complications, including new onset hypertension and heart injury were common in severe patients with COVID-19. More detailed researches in cardiovascular involvement in COVID-19 are urgently needed to further understand the disease.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Comorbidity / Coronavirus Infections / Hospitalization Type of study: Observational study / Risk factors Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: BMC Infect Dis Journal subject: Communicable Diseases Year: 2020 Document Type: Article Affiliation country: S12879-020-05452-2

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Comorbidity / Coronavirus Infections / Hospitalization Type of study: Observational study / Risk factors Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: BMC Infect Dis Journal subject: Communicable Diseases Year: 2020 Document Type: Article Affiliation country: S12879-020-05452-2