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SARS-CoV-2 antibody prevalence, titres and neutralising activity in an antenatal cohort, United Kingdom, 14 April to 15 June 2020.
Lumley, Sheila F; Eyre, David W; McNaughton, Anna L; Howarth, Alison; Hoosdally, Sarah; Hatch, Stephanie B; Kavanagh, James; Chau, Kevin K; Downs, Louise O; Cox, Stuart; Dunn, Laura; Justice, Anita; Wareing, Susan; Dingle, Kate; Rudkin, Justine; Auckland, Kathryn; Fyfe, Alexander; Bolton, Jai; Paton, Robert; Mentzer, Alexander J; Jeffery, Katie; Andersson, Monique I; James, Tim; Peto, Tim E A; Marsden, Brian D; Screaton, Gavin; Cornall, Richard J; Klenerman, Paul; Ebner, Daniel; Stuart, David I; Crook, Derrick W; Stoesser, Nicole; Kennedy, Stephen H; Thompson, Craig; Gupta, Sunetra; Matthews, Philippa C.
  • Lumley SF; These authors contributed equally to this work.
  • Eyre DW; Department of Microbiology/Infectious Diseases, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, United Kingdom.
  • McNaughton AL; Nuffield Department of Medicine, University of Oxford, Medawar Building, South Parks Road, Oxford, United Kingdom.
  • Howarth A; Nuffield Department of Population Health, University of Oxford, Big Data Institute, Old Road Campus, Oxford, United Kingdom.
  • Hoosdally S; These authors contributed equally to this work.
  • Hatch SB; Department of Microbiology/Infectious Diseases, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, United Kingdom.
  • Kavanagh J; Nuffield Department of Medicine, University of Oxford, Medawar Building, South Parks Road, Oxford, United Kingdom.
  • Chau KK; These authors contributed equally to this work.
  • Downs LO; Nuffield Department of Medicine, University of Oxford, Medawar Building, South Parks Road, Oxford, United Kingdom.
  • Cox S; Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom.
  • Dunn L; Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom.
  • Justice A; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Big Data Institute, Old Road Campus, Oxford, United Kingdom.
  • Wareing S; Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom.
  • Dingle K; Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom.
  • Rudkin J; Department of Microbiology/Infectious Diseases, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, United Kingdom.
  • Auckland K; Department of Clinical Biochemistry, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, United Kingdom.
  • Fyfe A; Department of Microbiology/Infectious Diseases, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, United Kingdom.
  • Bolton J; Department of Microbiology/Infectious Diseases, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, United Kingdom.
  • Paton R; Department of Microbiology/Infectious Diseases, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, United Kingdom.
  • Mentzer AJ; Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom.
  • Jeffery K; Nuffield Department of Population Health, University of Oxford, Big Data Institute, Old Road Campus, Oxford, United Kingdom.
  • Andersson MI; Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom.
  • James T; Department of Zoology, University of Oxford, Medawar Building, South Parks Road, Oxford, United Kingdom.
  • Peto TEA; Department of Zoology, University of Oxford, Medawar Building, South Parks Road, Oxford, United Kingdom.
  • Marsden BD; Department of Zoology, University of Oxford, Medawar Building, South Parks Road, Oxford, United Kingdom.
  • Screaton G; Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom.
  • Cornall RJ; Department of Microbiology/Infectious Diseases, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, United Kingdom.
  • Klenerman P; Department of Microbiology/Infectious Diseases, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, United Kingdom.
  • Ebner D; Department of Microbiology/Infectious Diseases, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, United Kingdom.
  • Stuart DI; Department of Clinical Biochemistry, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, United Kingdom.
  • Crook DW; Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom.
  • Stoesser N; Department of Microbiology/Infectious Diseases, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, United Kingdom.
  • Kennedy SH; The Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Henry Wellcome Building, Roosevelt Dr, Headington, Oxford, United Kingdom.
  • Thompson C; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford, United Kingdom.
  • Gupta S; Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Old Road Campus, Roosevelt Drive, Headington, Oxford, United Kingdom.
  • Matthews PC; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, Roosevelt Drive, Headington, Oxford, United Kingdom.
Euro Surveill ; 25(42)2020 10.
Article in English | MEDLINE | ID: covidwho-886127
ABSTRACT
SARS-CoV-2 IgG screening of 1,000 antenatal serum samples in the Oxford area, United Kingdom, between 14 April and 15 June 2020, yielded a 5.3% seroprevalence, mirroring contemporaneous regional data. Among the 53 positive samples, 39 showed in vitro neutralisation activity, correlating with IgG titre (Pearson's correlation p<0.0001). While SARS-CoV-2 seroprevalence in pregnancy cohorts could potentially inform population surveillance, clinical correlates of infection and immunity in pregnancy, and antenatal epidemiology evolution over time need further study.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Pregnancy Complications, Infectious / Pregnancy Trimester, First / Immunoglobulin G / Population Surveillance / Coronavirus Infections / Antibodies, Neutralizing / Pandemics / Betacoronavirus / Antibodies, Viral Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study / Randomized controlled trials Limits: Adolescent / Adult / Female / Humans / Middle aged / Pregnancy / Young adult Country/Region as subject: Europa Language: English Journal subject: Communicable Diseases Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Pregnancy Complications, Infectious / Pregnancy Trimester, First / Immunoglobulin G / Population Surveillance / Coronavirus Infections / Antibodies, Neutralizing / Pandemics / Betacoronavirus / Antibodies, Viral Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study / Randomized controlled trials Limits: Adolescent / Adult / Female / Humans / Middle aged / Pregnancy / Young adult Country/Region as subject: Europa Language: English Journal subject: Communicable Diseases Year: 2020 Document Type: Article