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An Overview of the Crystallized Structures of the SARS-CoV-2.
Ionescu, Mihaela Ileana.
  • Ionescu MI; Department of Microbiology, Iuliu Hațieganu University of Medicine and Pharmacy, 6 Louis Pasteur, 400349, Cluj-Napoca, Romania. mionescu@umfcluj.ro.
Protein J ; 39(6): 600-618, 2020 12.
Article in English | MEDLINE | ID: covidwho-1188139
ABSTRACT
Many research teams all over the world focus their research on the SARS-CoV-2, the new coronavirus that causes the so-called COVID-19 disease. Most of the studies identify the main protease or 3C-like protease (Mpro/3CLpro) as a valid target for large-spectrum inhibitors. Also, the interaction of the human receptor angiotensin-converting enzyme 2 (ACE2) with the viral surface glycoprotein (S) is studied in depth. Structural studies tried to identify the residues responsible for enhancement/weaken virus-ACE2 interactions or the cross-reactivity of the neutralizing antibodies. Although the understanding of the immune system and the hyper-inflammatory process in COVID-19 are crucial for managing the immediate and the long-term consequences of the disease, not many X-ray/NMR/cryo-EM crystals are available. In addition to 3CLpro, the crystal structures of other nonstructural proteins offer valuable information for elucidating some aspects of the SARS-CoV-2 infection. Thus, the structural analysis of the SARS-CoV-2 is currently mainly focused on three directions-finding Mpro/3CLpro inhibitors, the virus-host cell invasion, and the virus-neutralizing antibody interaction.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Coronavirus RNA-Dependent RNA Polymerase / Coronavirus Nucleocapsid Proteins / Coronavirus 3C Proteases / Coronavirus Papain-Like Proteases / SARS-CoV-2 / COVID-19 Type of study: Randomized controlled trials Limits: Humans Language: English Journal: Protein J Journal subject: Biochemistry Year: 2020 Document Type: Article Affiliation country: S10930-020-09933-w

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Coronavirus RNA-Dependent RNA Polymerase / Coronavirus Nucleocapsid Proteins / Coronavirus 3C Proteases / Coronavirus Papain-Like Proteases / SARS-CoV-2 / COVID-19 Type of study: Randomized controlled trials Limits: Humans Language: English Journal: Protein J Journal subject: Biochemistry Year: 2020 Document Type: Article Affiliation country: S10930-020-09933-w