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The Interaction of Natural and Vaccine-Induced Immunity with Social Distancing Predicts the Evolution of the COVID-19 Pandemic.
Good, Michael F; Hawkes, Michael T.
  • Good MF; Institute for Glycomics, Griffith University, Gold Coast Campus, Southport, Australia Michael.good@griffith.edu.au mthawkes@ualberta.ca.
  • Hawkes MT; University of Alberta, Edmonton, Canada.
mBio ; 11(5)2020 10 23.
Article in English | MEDLINE | ID: covidwho-887427
Semantic information from SemMedBD (by NLM)
1. Vaccines CAUSES Immunity
Subject
Vaccines
Predicate
CAUSES
Object
Immunity
2. Antibodie AFFECTS C0205082
Subject
Antibodie
Predicate
AFFECTS
Object
C0205082
3. Vaccines CAUSES Immunity
Subject
Vaccines
Predicate
CAUSES
Object
Immunity
4. Antibodies, Neutralizing AFFECTS Severe (severity modifier)
Subject
Antibodies, Neutralizing
Predicate
AFFECTS
Object
Severe (severity modifier)
ABSTRACT
The existence and nature of immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are currently unknown; however, neutralizing antibodies are thought to play the major role and data from studying other coronaviruses suggest that partial clinical immunity lasting up to 1 year will occur postinfection. We show how immunity, depending on its durability, may work with current social practices to limit the spread of the virus. We further show that a vaccine that is 50% effective and taken by 50% of the population will prevent further loss of life, providing that social distancing is still practiced and that immunity does not wane quickly.IMPORTANCE The ability of our society to function effectively moving forward will depend on how the spread of the SARS-CoV-2 virus is contained. Immunity to the virus will be critical to this equation.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Viral Vaccines / Coronavirus Infections / Pandemics / Betacoronavirus Type of study: Prognostic study / Risk factors Topics: Vaccines Limits: Humans Language: English Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Viral Vaccines / Coronavirus Infections / Pandemics / Betacoronavirus Type of study: Prognostic study / Risk factors Topics: Vaccines Limits: Humans Language: English Year: 2020 Document Type: Article