Your browser doesn't support javascript.
Perspective on Proteomics for Virus Detection in Clinical Samples.
Grossegesse, Marica; Hartkopf, Felix; Nitsche, Andreas; Schaade, Lars; Doellinger, Joerg; Muth, Thilo.
  • Grossegesse M; Centre for Biological Threats and Special Pathogens, Highly Pathogenic Viruses (ZBS 1), Robert Koch Institute, Seestr. 10, Berlin 13353, Germany.
  • Hartkopf F; Microbial Genomics (NG 1), Robert Koch Institute, Berlin 13353, Germany.
  • Nitsche A; Section eScience (S.3), Federal Institute for Materials Research and Testing, Unter den Eichen 87, Berlin 12205, Germany.
  • Schaade L; Centre for Biological Threats and Special Pathogens, Highly Pathogenic Viruses (ZBS 1), Robert Koch Institute, Seestr. 10, Berlin 13353, Germany.
  • Doellinger J; Centre for Biological Threats and Special Pathogens, Robert Koch Institute, Berlin 13353, Germany.
  • Muth T; Centre for Biological Threats and Special Pathogens, Proteomics and Spectroscopy (ZBS 6), Robert Koch Institute, Berlin 13353, Germany.
J Proteome Res ; 19(11): 4380-4388, 2020 11 06.
Article in English | MEDLINE | ID: covidwho-889125
ABSTRACT
One of the most widely used methods to detect an acute viral infection in clinical specimens is diagnostic real-time polymerase chain reaction. However, because of the COVID-19 pandemic, mass-spectrometry-based proteomics is currently being discussed as a potential diagnostic method for viral infections. Because proteomics is not yet applied in routine virus diagnostics, here we discuss its potential to detect viral infections. Apart from theoretical considerations, the current status and technical limitations are considered. Finally, the challenges that have to be overcome to establish proteomics in routine virus diagnostics are highlighted.
Subject(s)
Keywords
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Mass Spectrometry / Virology / Coronavirus Infections / Proteomics Type of study: Diagnostic study / Prognostic study Limits: Humans Language: English Journal: J Proteome Res Journal subject: Biochemistry Year: 2020 Document Type: Article Affiliation country: Acs.jproteome.0c00674

Similar

MEDLINE
LILACS
LIS
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Mass Spectrometry / Virology / Coronavirus Infections / Proteomics Type of study: Diagnostic study / Prognostic study Limits: Humans Language: English Journal: J Proteome Res Journal subject: Biochemistry Year: 2020 Document Type: Article Affiliation country: Acs.jproteome.0c00674