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Sustained Response After Remdesivir and Convalescent Plasma Therapy in a B-Cell-Depleted Patient With Protracted Coronavirus Disease 2019 (COVID-19).
Malsy, Jakob; Veletzky, Luzia; Heide, Janna; Hennigs, Annette; Gil-Ibanez, Ines; Stein, Alexander; Lütgehetmann, Marc; Rosien, Ulrich; Jasper, Dorothea; Peine, Sven; Hiller, Jens; Haag, Friedrich; Schmiedel, Stefan; Huber, Samuel; Jordan, Sabine; Addo, Marylyn M; Schulze Zur Wiesch, Julian.
  • Malsy J; Department of Medicine, Gastroenterology, and Hepatology, Sections of Infectious Diseases and Tropical Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Veletzky L; Department of Medicine, Gastroenterology, and Hepatology, Sections of Infectious Diseases and Tropical Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Heide J; Department of Medicine, Gastroenterology, and Hepatology, Sections of Infectious Diseases and Tropical Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Hennigs A; German Center for Infection Research (DZIF), Hamburg-Lubeck-Borstel-Riems, Germany.
  • Gil-Ibanez I; Department of Medicine, Gastroenterology, and Hepatology, Sections of Infectious Diseases and Tropical Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Stein A; Department of Medicine, Gastroenterology, and Hepatology, Sections of Infectious Diseases and Tropical Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Lütgehetmann M; Hämatologisch-Onkologische Praxis Eppendorf (HOPE), Hamburg, Germany.
  • Rosien U; University Cancer Center Hamburg (UCCH), Hamburg, Germany.
  • Jasper D; German Center for Infection Research (DZIF), Hamburg-Lubeck-Borstel-Riems, Germany.
  • Peine S; Institute of Medical Microbiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Hiller J; Department of Medicine, Israelitisches Krankenhaus, Hamburg, Germany.
  • Haag F; Department of Medicine, Israelitisches Krankenhaus, Hamburg, Germany.
  • Schmiedel S; Institute of Transfusion Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Huber S; Institute of Transfusion Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Jordan S; Department of Clinical Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Addo MM; Department of Medicine, Gastroenterology, and Hepatology, Sections of Infectious Diseases and Tropical Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Schulze Zur Wiesch J; Department of Medicine, Gastroenterology, and Hepatology, Sections of Infectious Diseases and Tropical Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Clin Infect Dis ; 73(11): e4020-e4024, 2021 12 06.
Article in English | MEDLINE | ID: covidwho-1560662
ABSTRACT
We provide detailed clinical, virological, and immunological data of a B-cell-depleted patient treated with obinutuzumab for follicular lymphoma with protracted coronavirus disease 2019 (COVID-19) and viremia. A sustained response was achieved after 2 courses of remdesivir and subsequent convalescent plasma therapy. Immunocompromised patients might require combined and prolonged antiviral treatment regimens.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / COVID-19 Drug Treatment Type of study: Prognostic study Limits: Humans Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: Cid

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / COVID-19 Drug Treatment Type of study: Prognostic study Limits: Humans Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: Cid