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Sustained Response After Remdesivir and Convalescent Plasma Therapy in a B-Cell-Depleted Patient With Protracted Coronavirus Disease 2019 (COVID-19).
Malsy, Jakob; Veletzky, Luzia; Heide, Janna; Hennigs, Annette; Gil-Ibanez, Ines; Stein, Alexander; Lütgehetmann, Marc; Rosien, Ulrich; Jasper, Dorothea; Peine, Sven; Hiller, Jens; Haag, Friedrich; Schmiedel, Stefan; Huber, Samuel; Jordan, Sabine; Addo, Marylyn M; Schulze Zur Wiesch, Julian.
  • Malsy J; Department of Medicine, Gastroenterology, and Hepatology, Sections of Infectious Diseases and Tropical Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Veletzky L; Department of Medicine, Gastroenterology, and Hepatology, Sections of Infectious Diseases and Tropical Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Heide J; Department of Medicine, Gastroenterology, and Hepatology, Sections of Infectious Diseases and Tropical Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Hennigs A; German Center for Infection Research (DZIF), Hamburg-Lubeck-Borstel-Riems, Germany.
  • Gil-Ibanez I; Department of Medicine, Gastroenterology, and Hepatology, Sections of Infectious Diseases and Tropical Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Stein A; Department of Medicine, Gastroenterology, and Hepatology, Sections of Infectious Diseases and Tropical Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Lütgehetmann M; Hämatologisch-Onkologische Praxis Eppendorf (HOPE), Hamburg, Germany.
  • Rosien U; University Cancer Center Hamburg (UCCH), Hamburg, Germany.
  • Jasper D; German Center for Infection Research (DZIF), Hamburg-Lubeck-Borstel-Riems, Germany.
  • Peine S; Institute of Medical Microbiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Hiller J; Department of Medicine, Israelitisches Krankenhaus, Hamburg, Germany.
  • Haag F; Department of Medicine, Israelitisches Krankenhaus, Hamburg, Germany.
  • Schmiedel S; Institute of Transfusion Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Huber S; Institute of Transfusion Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Jordan S; Department of Clinical Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Addo MM; Department of Medicine, Gastroenterology, and Hepatology, Sections of Infectious Diseases and Tropical Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Schulze Zur Wiesch J; Department of Medicine, Gastroenterology, and Hepatology, Sections of Infectious Diseases and Tropical Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Clin Infect Dis ; 73(11): e4020-e4024, 2021 12 06.
Article in English | MEDLINE | ID: covidwho-1560662
Semantic information from SemMedBD (by NLM)
1. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
2. B-Lymphocytes LOCATION_OF remdesivir
Subject
B-Lymphocytes
Predicate
LOCATION_OF
Object
remdesivir
3. obinutuzumab TREATS Patients
Subject
obinutuzumab
Predicate
TREATS
Object
Patients
4. obinutuzumab TREATS Lymphom
Subject
obinutuzumab
Predicate
TREATS
Object
Lymphom
5. obinutuzumab TREATS Viremia
Subject
obinutuzumab
Predicate
TREATS
Object
Viremia
6. obinutuzumab TREATS COVID-19
Subject
obinutuzumab
Predicate
TREATS
Object
COVID-19
7. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
8. B-Lymphocytes LOCATION_OF remdesivir
Subject
B-Lymphocytes
Predicate
LOCATION_OF
Object
remdesivir
9. obinutuzumab TREATS Patients
Subject
obinutuzumab
Predicate
TREATS
Object
Patients
10. obinutuzumab TREATS Lymphoma, Follicular
Subject
obinutuzumab
Predicate
TREATS
Object
Lymphoma, Follicular
11. obinutuzumab TREATS Viremia
Subject
obinutuzumab
Predicate
TREATS
Object
Viremia
12. obinutuzumab TREATS COVID-19
Subject
obinutuzumab
Predicate
TREATS
Object
COVID-19
ABSTRACT
We provide detailed clinical, virological, and immunological data of a B-cell-depleted patient treated with obinutuzumab for follicular lymphoma with protracted coronavirus disease 2019 (COVID-19) and viremia. A sustained response was achieved after 2 courses of remdesivir and subsequent convalescent plasma therapy. Immunocompromised patients might require combined and prolonged antiviral treatment regimens.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: Cid

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: Cid