Your browser doesn't support javascript.
Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 Replication in an Immunocompromised Patient.
Baang, Ji Hoon; Smith, Christopher; Mirabelli, Carmen; Valesano, Andrew L; Manthei, David M; Bachman, Michael A; Wobus, Christiane E; Adams, Michael; Washer, Laraine; Martin, Emily T; Lauring, Adam S.
  • Baang JH; Division of Infectious Diseases, University of Michigan, Ann Arbor, Michigan, USA.
  • Smith C; Division of Hospital Medicine, University of Michigan, Ann Arbor, Michigan, USA.
  • Mirabelli C; Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.
  • Valesano AL; Division of Infectious Diseases, University of Michigan, Ann Arbor, Michigan, USA.
  • Manthei DM; Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.
  • Bachman MA; Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA.
  • Wobus CE; Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA.
  • Adams M; Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.
  • Washer L; Division of Hospital Medicine, University of Michigan, Ann Arbor, Michigan, USA.
  • Martin ET; Division of Infectious Diseases, University of Michigan, Ann Arbor, Michigan, USA.
  • Lauring AS; Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA.
J Infect Dis ; 223(1): 23-27, 2021 01 04.
Article in English | MEDLINE | ID: covidwho-1066344
ABSTRACT
We describe a case of chronic coronavirus disease 2019 (COVID-19) in a patient with lymphoma and associated B-cell immunodeficiency. Viral cultures and sequence analysis demonstrate ongoing replication of infectious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) for at least 119 days. The patient had 3 admissions related to COVID-19 over a 4-month period and was treated twice with remdesivir and convalescent plasma with resolution of symptoms. The patient's lack of seroconversion and prolonged course illustrate the importance of humoral immunity in resolving SARS-CoV-2 infection. This case highlights challenges in managing immunocompromised hosts, who may act as persistent shedders and sources of transmission.
Subject(s)
Keywords
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: Available Collection: International databases Database: MEDLINE Main subject: Virus Replication / SARS-CoV-2 / COVID-19 Type of study: Case report / Diagnostic study / Prognostic study Topics: Long Covid Limits: Humans / Male / Middle aged Language: English Journal: J Infect Dis Year: 2021 Document Type: Article Affiliation country: Infdis

Similar

MEDLINE
LILACS
LIS
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: Available Collection: International databases Database: MEDLINE Main subject: Virus Replication / SARS-CoV-2 / COVID-19 Type of study: Case report / Diagnostic study / Prognostic study Topics: Long Covid Limits: Humans / Male / Middle aged Language: English Journal: J Infect Dis Year: 2021 Document Type: Article Affiliation country: Infdis