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COVID-19 and the Heart and Vasculature: Novel Approaches to Reduce Virus-Induced Inflammation in Patients With Cardiovascular Disease.
Kadosh, Bernard S; Garshick, Michael S; Gaztanaga, Juan; Moore, Kathryn J; Newman, Jonathan D; Pillinger, Michael; Ramasamy, Ravichandran; Reynolds, Harmony R; Shah, Binita; Hochman, Judith; Fishman, Glenn I; Katz, Stuart D.
  • Kadosh BS; From the Department of Medicine, Leon H. Charney Division of Cardiology, New York University Grossman School of Medicine (B.S.K., M.S.G., K.J.M., J.D.N., R.R., H.R.R., J.H., G.I.F., S.D.K.).
  • Garshick MS; From the Department of Medicine, Leon H. Charney Division of Cardiology, New York University Grossman School of Medicine (B.S.K., M.S.G., K.J.M., J.D.N., R.R., H.R.R., J.H., G.I.F., S.D.K.).
  • Gaztanaga J; Division of Internal Medicine, Department of Cardiology, NYU Winthrop Hospital, Mineola (J.G.).
  • Moore KJ; From the Department of Medicine, Leon H. Charney Division of Cardiology, New York University Grossman School of Medicine (B.S.K., M.S.G., K.J.M., J.D.N., R.R., H.R.R., J.H., G.I.F., S.D.K.).
  • Newman JD; From the Department of Medicine, Leon H. Charney Division of Cardiology, New York University Grossman School of Medicine (B.S.K., M.S.G., K.J.M., J.D.N., R.R., H.R.R., J.H., G.I.F., S.D.K.).
  • Pillinger M; Department of Medicine, Division of Rheumatology, New York, NY (M.P.).
  • Ramasamy R; VA New York Harbor Healthcare System, Department of Medicine (M.P., B.S.).
  • Reynolds HR; From the Department of Medicine, Leon H. Charney Division of Cardiology, New York University Grossman School of Medicine (B.S.K., M.S.G., K.J.M., J.D.N., R.R., H.R.R., J.H., G.I.F., S.D.K.).
  • Shah B; From the Department of Medicine, Leon H. Charney Division of Cardiology, New York University Grossman School of Medicine (B.S.K., M.S.G., K.J.M., J.D.N., R.R., H.R.R., J.H., G.I.F., S.D.K.).
  • Hochman J; VA New York Harbor Healthcare System, Department of Medicine (M.P., B.S.).
  • Fishman GI; From the Department of Medicine, Leon H. Charney Division of Cardiology, New York University Grossman School of Medicine (B.S.K., M.S.G., K.J.M., J.D.N., R.R., H.R.R., J.H., G.I.F., S.D.K.).
  • Katz SD; From the Department of Medicine, Leon H. Charney Division of Cardiology, New York University Grossman School of Medicine (B.S.K., M.S.G., K.J.M., J.D.N., R.R., H.R.R., J.H., G.I.F., S.D.K.).
Arterioscler Thromb Vasc Biol ; 40(9): 2045-2053, 2020 09.
Article in English | MEDLINE | ID: covidwho-889978
ABSTRACT
The coronavirus disease 2019 (COVID-19) pandemic presents an unprecedented challenge and opportunity for translational investigators to rapidly develop safe and effective therapeutic interventions. Greater risk of severe disease in COVID-19 patients with comorbid diabetes mellitus, obesity, and heart disease may be attributable to synergistic activation of vascular inflammation pathways associated with both COVID-19 and cardiometabolic disease. This mechanistic link provides a scientific framework for translational studies of drugs developed for treatment of cardiometabolic disease as novel therapeutic interventions to mitigate inflammation and improve outcomes in patients with COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Cardiovascular Diseases / Coronavirus Infections / Pandemics / Betacoronavirus / Inflammation Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: Arterioscler Thromb Vasc Biol Journal subject: Vascular Diseases Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Cardiovascular Diseases / Coronavirus Infections / Pandemics / Betacoronavirus / Inflammation Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: Arterioscler Thromb Vasc Biol Journal subject: Vascular Diseases Year: 2020 Document Type: Article