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Airborne transmission of SARS-CoV-2 via aerosols.
Comber, Laura; O Murchu, Eamon; Drummond, Linda; Carty, Paul G; Walsh, Kieran A; De Gascun, Cillian F; Connolly, Máire A; Smith, Susan M; O'Neill, Michelle; Ryan, Máirín; Harrington, Patricia.
  • Comber L; Health Technology Assessment Directorate, Health Information and Quality Authority, Dublin, Ireland.
  • O Murchu E; Health Technology Assessment Directorate, Health Information and Quality Authority, Dublin, Ireland.
  • Drummond L; Health Technology Assessment Directorate, Health Information and Quality Authority, Dublin, Ireland.
  • Carty PG; Health Technology Assessment Directorate, Health Information and Quality Authority, Dublin, Ireland.
  • Walsh KA; Health Technology Assessment Directorate, Health Information and Quality Authority, Dublin, Ireland.
  • De Gascun CF; National Virus Reference Laboratory, University College Dublin, Dublin, Ireland.
  • Connolly MA; School of Medicine, National University of Ireland Galway, Galway, Ireland.
  • Smith SM; Department of General Practice, Health Research Board Centre for Primary Care Research, Royal College of Surgeons in Ireland, Dublin, Ireland.
  • O'Neill M; Health Technology Assessment Directorate, Health Information and Quality Authority, Dublin, Ireland.
  • Ryan M; Health Technology Assessment Directorate, Health Information and Quality Authority, Dublin, Ireland.
  • Harrington P; Department of Pharmacology & Therapeutics, Trinity College Dublin, Dublin, Ireland.
Rev Med Virol ; 31(3): e2184, 2021 05.
Article in English | MEDLINE | ID: covidwho-891900
ABSTRACT
A key consideration in the Covid-19 pandemic is the dominant modes of transmission of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. The objective of this review was to synthesise the evidence for the potential airborne transmission of SARS-CoV-2 via aerosols. Systematic literature searches were conducted in PubMed, Embase, Europe PMC and National Health Service UK evidence up to 27 July 2020. A protocol was published and Cochrane guidance for rapid review methodology was adhered to throughout. Twenty-eight studies were identified. Seven out of eight epidemiological studies suggest aerosol transmission may occur, with enclosed environments and poor ventilation noted as possible contextual factors. Ten of the 16 air sampling studies detected SARS-CoV-2 ribonucleic acid; however, only three of these studies attempted to culture the virus with one being successful in a limited number of samples. Two of four virological studies using artificially generated aerosols indicated that SARS-CoV-2 is viable in aerosols. The results of this review indicate there is inconclusive evidence regarding the viability and infectivity of SARS-CoV-2 in aerosols. Epidemiological studies suggest possible transmission, with contextual factors noted. Viral particles have been detected in air sampling studies with some evidence of clinical infectivity, and virological studies indicate these particles may represent live virus, adding further plausibility. However, there is uncertainty as to the nature and impact of aerosol transmission of SARS-CoV-2, and its relative contribution to the Covid-19 pandemic compared with other modes of transmission.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: RNA, Viral / Aerosols / SARS-CoV-2 / COVID-19 Type of study: Observational study / Prognostic study / Reviews / Systematic review/Meta Analysis Limits: Humans Language: English Journal: Rev Med Virol Journal subject: Virology Year: 2021 Document Type: Article Affiliation country: Rmv.2184

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Full text: Available Collection: International databases Database: MEDLINE Main subject: RNA, Viral / Aerosols / SARS-CoV-2 / COVID-19 Type of study: Observational study / Prognostic study / Reviews / Systematic review/Meta Analysis Limits: Humans Language: English Journal: Rev Med Virol Journal subject: Virology Year: 2021 Document Type: Article Affiliation country: Rmv.2184