Your browser doesn't support javascript.
Topoisomerase III-ß is required for efficient replication of positive-sense RNA viruses.
Prasanth, K Reddisiva; Hirano, Minato; Fagg, W Samuel; McAnarney, Eileen T; Shan, Chao; Xie, Xuping; Hage, Adam; Pietzsch, Colette A; Bukreyev, Alexander; Rajsbaum, Ricardo; Shi, Pei-Yong; Bedford, Mark T; Bradrick, Shelton S; Menachery, Vineet; Garcia-Blanco, Mariano A.
  • Prasanth KR; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.
  • Hirano M; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.
  • Fagg WS; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA; Transplant Division, Department of Surgery, University of Texas Medical Branch, Galveston, TX, USA.
  • McAnarney ET; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
  • Shan C; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.
  • Xie X; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.
  • Hage A; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
  • Pietzsch CA; Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA; Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA.
  • Bukreyev A; Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA; Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA.
  • Rajsbaum R; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA; Institute of Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX, USA.
  • Shi PY; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA; Institute of Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX, USA.
  • Bedford MT; Department of Epigenetics and Molecular Carcinogenesis, MD Anderson Cancer Center, Smithville, TX, USA.
  • Bradrick SS; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA; Institute of Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX, USA.
  • Menachery V; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
  • Garcia-Blanco MA; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA; Institute of Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX, USA; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore. Electronic addr
Antiviral Res ; 182: 104874, 2020 10.
Article in English | MEDLINE | ID: covidwho-891945
Preprint
This scientific journal article is probably based on a previously available preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
See preprint
ABSTRACT
Based on genome-scale loss-of-function screens we discovered that Topoisomerase III-ß (TOP3B), a human topoisomerase that acts on DNA and RNA, is required for yellow fever virus and dengue virus-2 replication. Remarkably, we found that TOP3B is required for efficient replication of all positive-sense-single stranded RNA viruses tested, including SARS-CoV-2. While there are no drugs that specifically inhibit this topoisomerase, we posit that TOP3B is an attractive anti-viral target.
Subject(s)
Keywords
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: Available Collection: International databases Database: MEDLINE Main subject: RNA Viruses / Virus Replication / DNA Topoisomerases, Type I / Betacoronavirus Limits: Humans Language: English Journal: Antiviral Res Year: 2020 Document Type: Article Affiliation country: J.antiviral.2020.104874

Similar

MEDLINE
LILACS
LIS
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: Available Collection: International databases Database: MEDLINE Main subject: RNA Viruses / Virus Replication / DNA Topoisomerases, Type I / Betacoronavirus Limits: Humans Language: English Journal: Antiviral Res Year: 2020 Document Type: Article Affiliation country: J.antiviral.2020.104874