Current Evidence of 2019 Novel Coronavirus Disease (COVID-19) Ocular Transmission: A Systematic Review and Meta-Analysis.
Biomed Res Int
; 2020: 7605453, 2020.
Article
in English
| MEDLINE | ID: covidwho-892318
ABSTRACT
OBJECTIVE:
To estimate the prevalence rate of ocular symptoms and the positive rate of conjunctival swab samples of patients diagnosed with 2019 Novel Coronavirus Disease (COVID-19).METHODS:
We performed a systematic review and meta-analysis. A comprehensive literature search was done based on PubMed, Embase, MedRxiv, and the Cochrane Library. The primary outcomes are the prevalence rate of conjunctivitis/conjunctival congestion and the positive rate of conjunctival swab samples. Rates were expressed as proportions with 95% confidence intervals (CIs).RESULTS:
A total of 12 studies with 1930 participants were included for meta-analysis. The pooled prevalence rate of conjunctivitis/conjunctival congestion was 8% (95% CI 5%-12%). 1% (95% CI 1%-4%) of COVID-19 patients were diagnosed with conjunctivitis/conjunctival congestion as the initial symptom. The pooled positive rate of conjunctival swab samples was 3% (95% CI 2%-5%). We also assessed other ocular symptoms reported in the 12 studies, including foreign body sensation, increased secretion, and eye itching. The pooled prevalence rates were 6% (95% CI 3%-10%), 10% (95% CI 8%-12%), and 9% (95% CI 7%-10%), respectively.CONCLUSIONS:
The evidence on the positive rate of conjunctival swab samples and the prevalence rates of ocular symptoms indicated that COVID-19 ocular transmission was possible but less likely.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Eye
/
SARS-CoV-2
/
COVID-19
Type of study:
Observational study
/
Reviews
/
Systematic review/Meta Analysis
Limits:
Humans
Language:
English
Journal:
Biomed Res Int
Year:
2020
Document Type:
Article
Affiliation country:
2020
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