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Global impact of the COVID-19 pandemic on cytopathology practice: Results from an international survey of laboratories in 23 countries.
Vigliar, Elena; Cepurnaite, Rima; Alcaraz-Mateos, Eduardo; Ali, Syed Z; Baloch, Zubair W; Bellevicine, Claudio; Bongiovanni, Massimo; Botsun, Pavlina; Bruzzese, Dario; Bubendorf, Lukas; Büttner, Reinhard; Canberk, Sule; Capitanio, Arrigo; Casadio, Chiara; Cazacu, Eugeniu; Cochand-Priollet, Beatrix; D'Amuri, Alessandro; Eloy, Catarina; Engels, Marianne; Fadda, Guido; Fontanini, Gabriella; Fulciniti, Franco; Hofman, Paul; Iaccarino, Antonino; Ieni, Antonio; Jiang, Xiaoyin Sara; Kakudo, Kennichi; Kern, Izidor; Kholova, Ivana; Liu, Chinhua; Lobo, Anandi; Lozano, Maria D; Malapelle, Umberto; Maleki, Zahra; Michelow, Pamela; Musayev, Jamal; Özgün, Gonca; Oznur, Meltem; Peiró Marqués, Francisca Maria; Pisapia, Pasquale; Poller, David; Pyzlak, Michal; Robinson, Betsy; Rossi, Esther Diana; Roy-Chowdhuri, Sinchita; Saieg, Mauro; Savic Prince, Spasenija; Schmitt, Fernando C; Javier Seguí Iváñez, Francisco; Stoos-Veic, Tajana.
  • Vigliar E; Department of Public Health, University of Naples Federico II, Naples, Italy.
  • Cepurnaite R; Department of Public Health, University of Naples Federico II, Naples, Italy.
  • Alcaraz-Mateos E; Pathology Department, Jose M. Morales Meseguer University General Hospital, Murcia, Spain.
  • Ali SZ; Division of Cytopathology, Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland.
  • Baloch ZW; Department of Pathology, University of Pennsylvania, Philadelphia, Pennsylvania.
  • Bellevicine C; Department of Public Health, University of Naples Federico II, Naples, Italy.
  • Bongiovanni M; Cytopathology, SYNLAB Suisse SA, Lausanne, Switzerland.
  • Botsun P; Laboratory of Pathology CSD, Kyiv, Ukraine.
  • Bruzzese D; Department of Public Health, University of Naples Federico II, Naples, Italy.
  • Bubendorf L; Institute of Pathology, University Hospital Basel, Basel, Switzerland.
  • Büttner R; Department of Pathology, University Hospital Cologne, Cologne, Germany.
  • Canberk S; Medical Faculty, IPATIMUP, Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal.
  • Capitanio A; Department of Pathology, Linkoping University Hospital, Linkoping, Sweden.
  • Casadio C; Division of Pathology and Laboratory Medicine, European Institute of Oncology, Milan, Italy.
  • Cazacu E; Department of Morphopathology, Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, Moldova.
  • Cochand-Priollet B; Cochin Hospital, APHP University Medical Center of Paris, Paris, France.
  • D'Amuri A; Anatomic Pathology Unit, A. Perrino Hospital, ASL Brindisi, Brindisi, Italy.
  • Eloy C; Medical Faculty, IPATIMUP, Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal.
  • Engels M; Department of Pathology, University Hospital Cologne, Cologne, Germany.
  • Fadda G; Section of Pathological Anatomy, Department of Human Pathology "Gaetano Barresi", A.O.U. Polyclinic G. Martino, Messina, Italy.
  • Fontanini G; Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy.
  • Fulciniti F; Clinical Cytopathology Service, Histopathology Service, Cantonal Institute of Pathology, Locarno Cantonal Hospital, Locarno, Switzerland.
  • Hofman P; Laboratory of Clinical and Experimental Pathology, Hospital-related Biobank (BB-0033-00025), FHU OncoAge, Pasteur Hospital, Nice, France.
  • Iaccarino A; Department of Public Health, University of Naples Federico II, Naples, Italy.
  • Ieni A; Section of Pathological Anatomy, Department of Human Pathology "Gaetano Barresi", A.O.U. Polyclinic G. Martino, Messina, Italy.
  • Jiang XS; Department of Pathology, Duke University Medical Center, Durham, North Carolina.
  • Kakudo K; Department of Pathology, Izumi City General Hospital, Izumi, Japan.
  • Kern I; University Clinic Golnik, Golnik, Slovenia.
  • Kholova I; Department of Pathology, Fimlab Laboratories, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
  • Liu C; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Lobo A; Department of Pathology, Kapoor Path Laboratories, Raipur, India.
  • Lozano MD; Department of Pathology, University Clinic of Navarra, Pamplona, Spain.
  • Malapelle U; Department of Public Health, University of Naples Federico II, Naples, Italy.
  • Maleki Z; Division of Cytopathology, Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland.
  • Michelow P; Department of Anatomical Pathology, University of the Witwatersrand, National Health Laboratory Service, Johannesburg, South Africa.
  • Musayev J; Baku Pathology Center, Baku, Azerbaijan.
  • Özgün G; Department of Pathology, Baskent University Faculty of Medicine, Ankara, Turkey.
  • Oznur M; Department of Pathology, Tekirdag Namik Kemal University, Suleymanpasa/Tekirdag, Turkey.
  • Peiró Marqués FM; Department of Pathology, General University Hospital of Alicante, Alicante, Spain.
  • Pisapia P; Department of Public Health, University of Naples Federico II, Naples, Italy.
  • Poller D; Department of Pathology and Cytology, Queen Alexandra Hospital, Portsmouth, United Kingdom.
  • Pyzlak M; Center for Diagnostic Pathology, Warsaw, Poland.
  • Robinson B; Department of Pathology, Duke University Medical Center, Durham, North Carolina.
  • Rossi ED; Division of Anatomic Pathology and Histology, Catholic University-University Polyclinic Foundation "A. Gemini," Rome, Italy.
  • Roy-Chowdhuri S; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Saieg M; Department of Pathology, A.C. Camargo Cancer Center, Santa Casa Medical School, Sao Paulo, Brazil.
  • Savic Prince S; Institute of Pathology, University Hospital Basel, Basel, Switzerland.
  • Schmitt FC; Medical Faculty, IPATIMUP, Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal.
  • Javier Seguí Iváñez F; Department of Pathology, General University Hospital of Alicante, Alicante, Spain.
  • Stoos-Veic T; Department of Pathology and Cytology, University Hospital Dubrava, Zagreb, Croatia.
Cancer Cytopathol ; 128(12): 885-894, 2020 Dec.
Article in English | MEDLINE | ID: covidwho-893212
ABSTRACT

BACKGROUND:

To the authors' knowledge, the impact of the coronavirus disease 2019 (COVID-19) pandemic on cytopathology practices worldwide has not been investigated formally. In the current study, data from 41 respondents from 23 countries were reported.

METHODS:

Data regarding the activity of each cytopathology laboratory during 4 weeks of COVID-19 lockdown were collected and compared with those obtained during the corresponding period in 2019. The overall number and percentage of exfoliative and fine-needle aspiration cytology samples from each anatomic site were recorded. Differences in the malignancy and suspicious rates between the 2 periods were analyzed using a meta-analytical approach.

RESULTS:

Overall, the sample volume was lower compared with 2019 (104,319 samples vs 190,225 samples), with an average volume reduction of 45.3% (range, 0.1%-98.0%). The percentage of samples from the cervicovaginal tract, thyroid, and anorectal region was significantly reduced (P < .05). Conversely, the percentage of samples from the urinary tract, serous cavities, breast, lymph nodes, respiratory tract, salivary glands, central nervous system, gastrointestinal tract, pancreas, liver, and biliary tract increased (P < .05). An overall increase of 5.56% (95% CI, 3.77%-7.35%) in the malignancy rate in nongynecological samples during the COVID-19 pandemic was observed. When the suspicious category was included, the overall increase was 6.95% (95% CI, 4.63%-9.27%).

CONCLUSIONS:

The COVID-19 pandemic resulted in a drastic reduction in the total number of cytology specimens regardless of anatomic site or specimen type. The rate of malignancy increased, reflecting the prioritization of patients with cancer who were considered to be at high risk. Prospective monitoring of the effect of delays in access to health services during the lockdown period is warranted.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pathology, Clinical / Laboratories, Hospital / Communicable Disease Control / Workload / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials / Reviews Limits: Humans Language: English Journal: Cancer Cytopathol Year: 2020 Document Type: Article Affiliation country: Cncy.22373

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pathology, Clinical / Laboratories, Hospital / Communicable Disease Control / Workload / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials / Reviews Limits: Humans Language: English Journal: Cancer Cytopathol Year: 2020 Document Type: Article Affiliation country: Cncy.22373