Monocyte HLA-DR Measurement by Flow Cytometry in COVID-19 Patients: An Interim Review.
Cytometry A
; 97(12): 1217-1221, 2020 12.
Article
in English
| MEDLINE | ID: covidwho-893217
ABSTRACT
Several months after the sudden emergence of SARS-CoV-2 and COVID-19, the understanding of the appropriate host immune response to a virus totally unknown of human immune surveillance is still of major importance. By international definition, COVID-19 falls in the scope of septic syndromes (organ dysfunction due to dysregulated host response to an infection) in which immunosuppression is a significant driver of mortality. Sepsis-induced immunosuppression is mostly defined and monitored by the measurement of decreased expression of HLA-DR molecules on circulating monocytes (mHLA-DR). In this interim review, we summarize the first mHLA-DR results in COVID-19 patients. In critically ill patients, results homogenously indicate a decreased mHLA-DR expression, which, along with profound lymphopenia and other functional alterations, is indicative of a status of immunosuppression. © 2020 International Society for Advancement of Cytometry.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Monocytes
/
HLA-DR Antigens
/
COVID-19
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Cytometry A
Year:
2020
Document Type:
Article
Affiliation country:
Cyto.a.24249
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