COVID-19 and antimalarials. Have we been doing it wrong all along?
Eur J Pharmacol
; 891: 173694, 2021 Jan 15.
Article
in English
| MEDLINE | ID: covidwho-893746
ABSTRACT
In the context of the current SARS-CoV-2 pandemic, associations of drugs which interfere with specific steps of the viral infectious cycle are currently being exploited as therapeutic strategies since a specific treatment by vaccination is still unavailable. A widespread association of repurposed agents is the combination of the antimalarial drug Hydroxychloroquine and the macrolide antibiotic Azithromycin in the setting of clinical trials. But a closer analysis of their mechanism of action suggests that their concomitant administration may be impractical, and this is supported by experimental data with other agents of the same classes. However a sequential administration of the lysosomotropic antimalarial with the addition of the macrolide proton pump inhibitor after the first has reached a certain threshold could better exploit their antiviral potential.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Azithromycin
/
Drug Repositioning
/
SARS-CoV-2
/
COVID-19
/
COVID-19 Drug Treatment
/
Hydroxychloroquine
Type of study:
Prognostic study
Topics:
Vaccines
Limits:
Humans
Language:
English
Journal:
Eur J Pharmacol
Year:
2021
Document Type:
Article
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