Your browser doesn't support javascript.
COVID-19 outpatients: early risk-stratified treatment with zinc plus low-dose hydroxychloroquine and azithromycin: a retrospective case series study.
Derwand, Roland; Scholz, Martin; Zelenko, Vladimir.
  • Derwand R; Alexion Pharma Germany GmbH, 80687, Munich, Germany.
  • Scholz M; Heinrich-Heine-University, Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Germany. Electronic address: scholzmartin19@gmail.com.
  • Zelenko V; Medical Group Practice, Monroe, NY, 10950, USA.
Int J Antimicrob Agents ; 56(6): 106214, 2020 Dec.
Article in English | MEDLINE | ID: covidwho-893921
ABSTRACT
The aim of this study was to describe the outcomes of patients with coronavirus disease 2019 (COVID-19) in the outpatient setting after early treatment with zinc, low-dose hydroxychloroquine and azithromycin (triple therapy) dependent on risk stratification. This was a retrospective case series study in the general practice setting. A total of 141 COVID-19 patients with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the year 2020 were included. The main outcome measures were risk-stratified treatment decision and rates of hospitalisation and all-cause death. A median of 4 days [interquartile range (IQR) 3-6 days; available for n = 66/141 patients] after the onset of symptoms, 141 patients (median age 58 years, IQR 40-67 years; 73.0% male) received a prescription for triple therapy for 5 days. Independent public reference data from 377 confirmed COVID-19 patients in the same community were used as untreated controls. Of 141 treated patients, 4 (2.8%) were hospitalised, which was significantly fewer (P < 0.001) compared with 58 (15.4%) of 377 untreated patients [odds ratio (OR) = 0.16, 95% confidence interval (CI) 0.06-0.5]. One patient (0.7%) in the treatment group died versus 13 patients (3.4%) in the untreated group (OR = 0.2, 95% CI 0.03-1.5; P = 0.12). No cardiac side effects were observed. Risk stratification-based treatment of COVID-19 outpatients as early as possible after symptom onset using triple therapy, including the combination of zinc with low-dose hydroxychloroquine, was associated with significantly fewer hospitalisations.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Zinc / Azithromycin / SARS-CoV-2 / COVID-19 Drug Treatment / Hydroxychloroquine Type of study: Observational study / Prognostic study Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Int J Antimicrob Agents Year: 2020 Document Type: Article Affiliation country: J.ijantimicag.2020.106214

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Zinc / Azithromycin / SARS-CoV-2 / COVID-19 Drug Treatment / Hydroxychloroquine Type of study: Observational study / Prognostic study Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Int J Antimicrob Agents Year: 2020 Document Type: Article Affiliation country: J.ijantimicag.2020.106214