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A multiple therapy hypothesis for treatment of COVID-19 patients.
Oscar, Thomas P.
  • Oscar TP; U.S. Department of Agriculture, Agricultural Research Service, Chemical Residue and Predictive Microbiology Research Unit, Room 2111, Center for Food Science and Technology, University of Maryland Eastern Shore, Princess Anne, MD 21853, United States. Electronic address: thomas.oscar@usda.gov.
Med Hypotheses ; 145: 110353, 2020 Dec.
Article in English | MEDLINE | ID: covidwho-894130
ABSTRACT
The coronavirus disease 2019 (COVID-19) pandemic, which is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has killed more than one million people as of October 1, 2020. Consequently, a search is on for a treatment that can bring the pandemic to an end. However, treatments (vaccine, antiviral, plasma) that are directed at specific viral proteins (RNA polymerase, spike proteins) may not work well against all strains of the virus. Therefore, it is hypothesized that a therapy based on multiple treatments is needed for COVID-19 patients and to bring the pandemic to an end. Here, it is proposed that a combination of cool air therapy (CAT) and purified air technology (PAT) in an oxygen species cool air respirator (OSCAR) could be used to reduce viral (SARS-CoV-2) load and severity of illness in COVID-19 patients through the individual dose-response relationship. In addition, the proposed therapy (CAT + PAT in OSCAR), which works by a more general physical and chemical mechanism, should work well with other treatments (vaccine, antiviral, plasma) that target specific viral proteins (RNA polymerase, spike proteins) to provide a safe and effective multiple therapy approach for ending the COVID-19 pandemic caused by SARS-CoV-2.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Oxygen / Combined Modality Therapy / Air / COVID-19 Type of study: Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Med Hypotheses Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Oxygen / Combined Modality Therapy / Air / COVID-19 Type of study: Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Med Hypotheses Year: 2020 Document Type: Article