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Crystal structure of SARS-CoV-2 main protease in complex with the natural product inhibitor shikonin illuminates a unique binding mode.
Li, Jian; Zhou, Xuelan; Zhang, Yan; Zhong, Fanglin; Lin, Cheng; McCormick, Peter J; Jiang, Feng; Luo, Jun; Zhou, Huan; Wang, Qisheng; Fu, Yang; Duan, Jingjing; Zhang, Jin.
  • Li J; College of Pharmaceutical Sciences, Gannan Medical University, Ganzhou 341000, China.
  • Zhou X; School of Basic Medical Sciences, Nanchang University, Nanchang 330031, China.
  • Zhang Y; The Second Affiliated Hospital of Nanchang University, Nanchang 330031, China.
  • Zhong F; Shenzhen Crystalo Biopharmaceutical Co., Ltd, Shenzhen 518118, China.
  • Lin C; Jiangxi Jmerry Biopharmaceutical Co., Ltd, Ganzhou 341000, China.
  • McCormick PJ; Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical University, Ganzhou 341000, China.
  • Jiang F; William Harvey Research Institute, Bart's and the London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
  • Luo J; College of Pharmaceutical Sciences, Gannan Medical University, Ganzhou 341000, China.
  • Zhou H; The Second Affiliated Hospital of Nanchang University, Nanchang 330031, China.
  • Wang Q; Shanghai Synchrotron Radiation Facility, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201204, China.
  • Fu Y; Shanghai Synchrotron Radiation Facility, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201204, China.
  • Duan J; School of Medicine, Southern University of Science and Technology, Shenzhen 518055, China.
  • Zhang J; Human Aging Research Institute (HARI), School of Life Sciences, Nanchang University, Nanchang 330031, China.
Sci Bull (Beijing) ; 66(7): 661-663, 2021 Apr 15.
Article in English | MEDLINE | ID: covidwho-894202
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Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: Sci Bull (Beijing) Year: 2021 Document Type: Article Affiliation country: J.scib.2020.10.018

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Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: Sci Bull (Beijing) Year: 2021 Document Type: Article Affiliation country: J.scib.2020.10.018