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Antihypertensive drugs are associated with reduced fatal outcomes and improved clinical characteristics in elderly COVID-19 patients.
Yan, Feifei; Huang, Fengming; Xu, Jun; Yang, Penghui; Qin, Yuhao; Lv, Jingjun; Zhang, Shaogeng; Ye, Lu; Gong, Ming; Liu, Zhibo; Wei, Jie; Xie, Tuxiu; Xu, Kai-Feng; Gao, George F; Wang, Fu-Sheng; Cai, Lin; Jiang, Chengyu.
  • Yan F; Department of Orthopedics, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, 430071, China.
  • Huang F; Department of Medical Quality Control, Leishenshan Hospital, Wuhan, Hubei, 430000, China.
  • Xu J; The State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Department of Biochemistry, Peking Union Medical College, Beijing, 100005, China.
  • Yang P; Emergency Department, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730, China.
  • Qin Y; Fifth Medical Center of Chinese PLA General Hospital, Beijing, 100039, China.
  • Lv J; The State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Department of Biochemistry, Peking Union Medical College, Beijing, 100005, China.
  • Zhang S; Emergency Department, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, China.
  • Ye L; Fifth Medical Center of Chinese PLA General Hospital, Beijing, 100039, China.
  • Gong M; Emergency Department, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, China.
  • Liu Z; Department of Orthopedics, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, 430071, China.
  • Wei J; Department of Orthopedics, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, 430071, China.
  • Xie T; Emergency Department, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, China.
  • Xu KF; General Medicine Department, Guang-gu Division of Renmin Hospital of Wuhan University, Wuhan, Hubei, 430200, China.
  • Gao GF; Department of Pulmonary and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730, China.
  • Wang FS; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.
  • Cai L; Fifth Medical Center of Chinese PLA General Hospital, Beijing, 100039, China.
  • Jiang C; Department of Orthopedics, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, 430071, China. orthopedics@whu.edu.cn.
Cell Discov ; 6(1): 77, 2020 Oct 29.
Article in English | MEDLINE | ID: covidwho-894383
ABSTRACT
The novel coronavirus (CoV) severe acute respiratory syndrome (SARS)-CoV-2 outbreak began at the end of 2019 in Wuhan, China, and has spread to over 200 countries. In this multicenter retrospective study, we identified 2190 adult patients admitted for laboratory-confirmed COVID-19 in three participating centers. Multivariate logistic regression was conducted in patients with comorbid hypertension to examine the potential association between clinical outcomes, disease severity, and clinical characteristics with the use of ACEI, ARB, calcium-channel blockers (CCB), beta-blockers (BB), and thiazide diuretics. The clinical outcome, dyspnea, and fatigue were significantly improved in patients, especially elderly patients who were older than 65 years, who took ARB drugs prior to hospitalization compared to patients who took no drugs. The reduction of disease severity of elderly COVID-19 patients was associated with CCB and ACEI users. Clinical indices, including CRP, lymphocyte count, procalcitonin D dimer, and hemoglobin, were significantly improved in elderly ARB users. In addition, the clinical outcomes were statistically significantly improved in patients who took antihypertension drugs ARB, BB, and CCB after statistical adjustment by all ages, gender, baseline of blood pressures, and coexisting medical conditions. Our data indicate that hypertension drugs ARB, ACEI, CCB, and BB might be beneficial for COVID-19 patients.

Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study Language: English Journal: Cell Discov Year: 2020 Document Type: Article Affiliation country: S41421-020-00221-6

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study Language: English Journal: Cell Discov Year: 2020 Document Type: Article Affiliation country: S41421-020-00221-6