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SARS-CoV-2 viral load is associated with increased disease severity and mortality.
Fajnzylber, Jesse; Regan, James; Coxen, Kendyll; Corry, Heather; Wong, Colline; Rosenthal, Alexandra; Worrall, Daniel; Giguel, Francoise; Piechocka-Trocha, Alicja; Atyeo, Caroline; Fischinger, Stephanie; Chan, Andrew; Flaherty, Keith T; Hall, Kathryn; Dougan, Michael; Ryan, Edward T; Gillespie, Elizabeth; Chishti, Rida; Li, Yijia; Jilg, Nikolaus; Hanidziar, Dusan; Baron, Rebecca M; Baden, Lindsey; Tsibris, Athe M; Armstrong, Katrina A; Kuritzkes, Daniel R; Alter, Galit; Walker, Bruce D; Yu, Xu; Li, Jonathan Z.
  • Fajnzylber J; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Regan J; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Coxen K; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Corry H; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Wong C; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Rosenthal A; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Worrall D; Ragon Institute of MGH, MIT and Harvard, Harvard Medical School, Cambridge, MA, USA.
  • Giguel F; Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Piechocka-Trocha A; Ragon Institute of MGH, MIT and Harvard, Harvard Medical School, Cambridge, MA, USA.
  • Atyeo C; Ragon Institute of MGH, MIT and Harvard, Harvard Medical School, Cambridge, MA, USA.
  • Fischinger S; Ragon Institute of MGH, MIT and Harvard, Harvard Medical School, Cambridge, MA, USA.
  • Chan A; Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Flaherty KT; Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Hall K; Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Dougan M; Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Ryan ET; Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Gillespie E; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Chishti R; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Li Y; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Jilg N; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Hanidziar D; Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Baron RM; Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Baden L; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Tsibris AM; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Armstrong KA; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Kuritzkes DR; Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Alter G; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Walker BD; Ragon Institute of MGH, MIT and Harvard, Harvard Medical School, Cambridge, MA, USA.
  • Yu X; Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Li JZ; Ragon Institute of MGH, MIT and Harvard, Harvard Medical School, Cambridge, MA, USA.
Nat Commun ; 11(1): 5493, 2020 10 30.
Article in English | MEDLINE | ID: covidwho-894389
Preprint
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ABSTRACT
The relationship between SARS-CoV-2 viral load and risk of disease progression remains largely undefined in coronavirus disease 2019 (COVID-19). Here, we quantify SARS-CoV-2 viral load from participants with a diverse range of COVID-19 disease severity, including those requiring hospitalization, outpatients with mild disease, and individuals with resolved infection. We detected SARS-CoV-2 plasma RNA in 27% of hospitalized participants, and 13% of outpatients diagnosed with COVID-19. Amongst the participants hospitalized with COVID-19, we report that a higher prevalence of detectable SARS-CoV-2 plasma viral load is associated with worse respiratory disease severity, lower absolute lymphocyte counts, and increased markers of inflammation, including C-reactive protein and IL-6. SARS-CoV-2 viral loads, especially plasma viremia, are associated with increased risk of mortality. Our data show that SARS-CoV-2 viral loads may aid in the risk stratification of patients with COVID-19, and therefore its role in disease pathogenesis should be further explored.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Betacoronavirus Type of study: Cohort study / Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Middle aged Country/Region as subject: North America Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2020 Document Type: Article Affiliation country: S41467-020-19057-5

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Betacoronavirus Type of study: Cohort study / Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Middle aged Country/Region as subject: North America Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2020 Document Type: Article Affiliation country: S41467-020-19057-5