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Kinetics of SARS-CoV-2 positivity of infected and recovered patients from a single center.
Huang, Jia; Zheng, Le; Li, Zhen; Hao, Shiying; Ye, Fangfan; Chen, Jun; Gans, Hayley A; Yao, Xiaoming; Liao, Jiayu; Wang, Song; Zeng, Manfei; Qiu, Liping; Li, Chunyang; Whitin, John C; Tian, Lu; Chubb, Henry; Hwa, Kuo-Yuan; Ceresnak, Scott R; Zhang, Wei; Lu, Ying; Maldonado, Yvonne A; McElhinney, Doff B; Sylvester, Karl G; Cohen, Harvey J; Liu, Lei; Ling, Xuefeng B.
  • Huang J; National Clinical Research Center for Infectious Disease, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong Province, China.
  • Zheng L; Department of Surgery, Stanford University School of Medicine, Stanford, CA, 94305, USA.
  • Li Z; Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, USA.
  • Hao S; Clinical and Translational Research Program, Betty Irene Moore Children's Heart Center, Lucile Packard Children's Hospital, Palo Alto, CA, USA.
  • Ye F; Department of Surgery, Stanford University School of Medicine, Stanford, CA, 94305, USA.
  • Chen J; Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, USA.
  • Gans HA; Clinical and Translational Research Program, Betty Irene Moore Children's Heart Center, Lucile Packard Children's Hospital, Palo Alto, CA, USA.
  • Yao X; National Clinical Research Center for Infectious Disease, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong Province, China.
  • Liao J; Department of Surgery, Stanford University School of Medicine, Stanford, CA, 94305, USA.
  • Wang S; National Clinical Research Center for Infectious Disease, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong Province, China. drchenjun@163.com.
  • Zeng M; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
  • Qiu L; Translational Medicine Laboratory, West China Hospital, Sichuan University, Chengdu, China.
  • Li C; Department of Bioengineering, University of California at Riverside, Riverside, CA, USA.
  • Whitin JC; National Clinical Research Center for Infectious Disease, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong Province, China.
  • Tian L; National Clinical Research Center for Infectious Disease, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong Province, China.
  • Chubb H; National Clinical Research Center for Infectious Disease, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong Province, China.
  • Hwa KY; Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, China.
  • Ceresnak SR; Medical Big Data Center, Sichuan University, Chengdu, China.
  • Zhang W; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
  • Lu Y; Department of Biomedical Data Science, Stanford University, Stanford, CA, USA.
  • Maldonado YA; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
  • McElhinney DB; Department of Medicine, The University of Hong Kong, Hong Kong, SAR, China.
  • Sylvester KG; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
  • Cohen HJ; Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, China.
  • Liu L; Medical Big Data Center, Sichuan University, Chengdu, China.
  • Ling XB; Department of Biomedical Data Science, Stanford University, Stanford, CA, USA.
Sci Rep ; 10(1): 18629, 2020 10 29.
Article in English | MEDLINE | ID: covidwho-894416
ABSTRACT
Recurrence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive detection in infected but recovered individuals has been reported. Patients who have recovered from coronavirus disease 2019 (COVID-19) could profoundly impact the health care system. We sought to define the kinetics and relevance of PCR-positive recurrence during recovery from acute COVID-19 to better understand risks for prolonged infectivity and reinfection. A series of 414 patients with confirmed SARS-Cov-2 infection, at The Second Affiliated Hospital of Southern University of Science and Technology in Shenzhen, China from January 11 to April 23, 2020. Statistical analyses were performed of the clinical, laboratory, radiologic image, medical treatment, and clinical course of admission/quarantine/readmission data, and a recurrence predictive algorithm was developed. 16.7% recovered patients with PCR positive recurring one to three times, despite being in strict quarantine. Younger patients with mild pulmonary respiratory syndrome had higher risk of PCR positivity recurrence. The recurrence prediction model had an area under the ROC curve of 0.786. This case series provides characteristics of patients with recurrent SARS-CoV-2 positivity. Use of a prediction algorithm may identify patients at high risk of recurrent SARS-CoV-2 positivity and help to establish protocols for health policy.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Clinical Laboratory Techniques / Hospitalization Type of study: Diagnostic study / Observational study / Prognostic study Limits: Humans Country/Region as subject: Asia Language: English Journal: Sci Rep Year: 2020 Document Type: Article Affiliation country: S41598-020-75629-x

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Clinical Laboratory Techniques / Hospitalization Type of study: Diagnostic study / Observational study / Prognostic study Limits: Humans Country/Region as subject: Asia Language: English Journal: Sci Rep Year: 2020 Document Type: Article Affiliation country: S41598-020-75629-x