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Potential of Ficus microcarpa metabolites against SARS-CoV-2 main protease supported by docking studies.
Hassan, Heba Ali; Abdelmohsen, Usama Ramadan; Aly, Omar M; Desoukey, Samar Y; Mohamed, Khaled M; Kamel, Mohamed S.
  • Hassan HA; Pharmacognosy Department, Faculty of Pharmacy, Deraya University, New Minia City, Egypt.
  • Abdelmohsen UR; Pharmacognosy Department, Faculty of Pharmacy, Deraya University, New Minia City, Egypt.
  • Aly OM; Pharmacognosy Department, Faculty of Pharmacy, Minia University, Minia, Egypt.
  • Desoukey SY; Medicinal Chemistry Department, Faculty of Pharmacy, Minia University, Minia, Egypt.
  • Mohamed KM; Pharmacognosy Department, Faculty of Pharmacy, Minia University, Minia, Egypt.
  • Kamel MS; Pharmacognosy Department Faculty of Pharmacy, Fayoum University, Fayoum, Egypt.
Nat Prod Res ; 36(4): 994-998, 2022 Feb.
Article in English | MEDLINE | ID: covidwho-894501
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1. Scientific Study DIAGNOSES activity level
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Scientific Study
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DIAGNOSES
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activity level
2. Scientific Study DIAGNOSES activity level
Subject
Scientific Study
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DIAGNOSES
Object
activity level
ABSTRACT
COVID 19; an infectious disease; firstly identified in December 2019 in Wuhan, China and has since spread globally, resulting in an ongoing pandemic. Searching for protease inhibitors is a challenging task in controlling COVID 19. Genus Ficus is known to be a rich source of phenolic compounds. Metabolic profiling of leaves methanolic extract of Ficus microcarpa (Moraceae) revealed nine compounds (1-9) mainly phenolics. Docking studies concerning these compounds against SARS-CoV-2 main protease showed that quercetin 3,7-O-α-L-dirhamnoside (1) and rutin (3) possessed significant binding stability at the N3 binding site in different activity degrees, which is comparable with COVID-19 main protease inhibitor, darunavir. Our study suggests that compounds quercetin 3,7-O-α-L-dirhamnoside and rutin might be potential candidates for the development of therapies against SARS-CoV-2.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Plant Extracts / Ficus / Coronavirus 3C Proteases / COVID-19 Limits: Humans Language: English Journal: Nat Prod Res Year: 2022 Document Type: Article Affiliation country: 14786419.2020.1839452

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Plant Extracts / Ficus / Coronavirus 3C Proteases / COVID-19 Limits: Humans Language: English Journal: Nat Prod Res Year: 2022 Document Type: Article Affiliation country: 14786419.2020.1839452