Potential of Ficus microcarpa metabolites against SARS-CoV-2 main protease supported by docking studies.
Nat Prod Res
; 36(4): 994-998, 2022 Feb.
Article
in English
| MEDLINE | ID: covidwho-894501
ABSTRACT
COVID 19; an infectious disease; firstly identified in December 2019 in Wuhan, China and has since spread globally, resulting in an ongoing pandemic. Searching for protease inhibitors is a challenging task in controlling COVID 19. Genus Ficus is known to be a rich source of phenolic compounds. Metabolic profiling of leaves methanolic extract of Ficus microcarpa (Moraceae) revealed nine compounds (1-9) mainly phenolics. Docking studies concerning these compounds against SARS-CoV-2 main protease showed that quercetin 3,7-O-α-L-dirhamnoside (1) and rutin (3) possessed significant binding stability at the N3 binding site in different activity degrees, which is comparable with COVID-19 main protease inhibitor, darunavir. Our study suggests that compounds quercetin 3,7-O-α-L-dirhamnoside and rutin might be potential candidates for the development of therapies against SARS-CoV-2.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Plant Extracts
/
Ficus
/
Coronavirus 3C Proteases
/
COVID-19 Drug Treatment
Limits:
Humans
Language:
English
Journal:
Nat Prod Res
Year:
2022
Document Type:
Article
Affiliation country:
14786419.2020.1839452
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