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Outcome of patients hospitalized for COVID-19 and exposure to angiotensin-converting enzyme inhibitors and angiotensin-receptor blockers in France: results of the ACE-CoV study.
Lafaurie, Margaux; Martin-Blondel, Guillaume; Delobel, Pierre; Charpentier, Sandrine; Sommet, Agnès; Moulis, Guillaume.
  • Lafaurie M; Service de Pharmacologie Médicale, Faculté de Médecine, Centre Hospitalier Universitaire de Toulouse, 37 allées Jules Guesde, Toulouse, 31000, France.
  • Martin-Blondel G; Centre d'Investigation Clinique 1436, axe pharmacoépidémiologie, Centre Hospitalier Universitaire de Toulouse-Purpan, place du Dr Baylac, TSA40031, Toulouse Cedex 9, 31059, France.
  • Delobel P; Service des Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire de Toulouse-Purpan, place du Dr Baylac, Toulouse Cedex 9, TSA40031, 31059, France.
  • Charpentier S; UMR INSERM/CNRS 1043, Centre de Physiopathologie Toulouse Purpan, 330 avenue de Grande-Bretagne, Toulouse cedex 9, 31059, France.
  • Sommet A; Service des Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire de Toulouse-Purpan, place du Dr Baylac, Toulouse Cedex 9, TSA40031, 31059, France.
  • Moulis G; UMR INSERM/CNRS 1043, Centre de Physiopathologie Toulouse Purpan, 330 avenue de Grande-Bretagne, Toulouse cedex 9, 31059, France.
Fundam Clin Pharmacol ; 35(1): 194-203, 2021 Feb.
Article in English | MEDLINE | ID: covidwho-894749
ABSTRACT
Data are lacking on the impact of ACEI/ARB exposure on unfavorable outcome in the population of patients hospitalized for COVID-19 with hypertension/cardiovascular disease, particularly in Europe. The ACE-CoV study was designed to assess this question. The study was conducted in the Covid-Clinic-Toul cohort, which contains data about all patients hospitalized at Toulouse University hospital, France with a SARS-CoV-2 infection since March, 2020. We selected the patients with a history of cardiovascular disease (heart failure or coronary disease) and/or arterial hypertension. We conducted a subgroup analysis in patients with arterial hypertension. ACEI/ARB exposures at admission were assessed. The outcome was composite admission to intensive care unit, need of mechanical ventilation or death during the 14 days after admission to hospital. We used logistic regression models with propensity scores (PS) weighted by overlap weighting (OW) and inverse probability of treatment weighting (IPTW). Between March 2020 and April 20, 2020, the Covid-Clinic-Toul included 263 patients. Among them, 111 were included in the ACE-CoV study population. In OW-PS-adjusted analyses, the association of exposure to ACEIs or ARBs with outcome occurrence was OR 1.56 (95% CI 0.73-3.33). It was 0.99 (95% CI 0.68-1.45) for ACEIs and 1.64 (95% CI 0.77-3.50) for ARBs. Analyses with weighting by the IPTW-PS method gave similar results. Results were similar when considering the subgroup of patients with arterial hypertension. The ACE-CoV study found no association between exposure to ACEIs or ARBs and unfavorable outcome in hospitalized patients for COVID-19 with a history of cardiovascular disease/arterial hypertension.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Angiotensin-Converting Enzyme Inhibitors / Peptidyl-Dipeptidase A / Angiotensin Receptor Antagonists / COVID-19 Drug Treatment Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Limits: Aged / Female / Humans / Male Country/Region as subject: Europa Language: English Journal: Fundam Clin Pharmacol Journal subject: Pharmacology Year: 2021 Document Type: Article Affiliation country: Fcp.12613

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Angiotensin-Converting Enzyme Inhibitors / Peptidyl-Dipeptidase A / Angiotensin Receptor Antagonists / COVID-19 Drug Treatment Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Limits: Aged / Female / Humans / Male Country/Region as subject: Europa Language: English Journal: Fundam Clin Pharmacol Journal subject: Pharmacology Year: 2021 Document Type: Article Affiliation country: Fcp.12613