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A Preclinical Safety Study of Thyroid Hormone Instilled into the Lungs of Healthy Rats-an Investigational Therapy for ARDS.
Flory, Craig M; Norris, Beverly J; Larson, Nicole A; Coicou, Lia G; Koniar, Brenda L; Mysz, Margaret A; Rich, Timothy P; Ingbar, David H; Schumacher, Robert J.
  • Flory CM; Pulmonology, Allergy, Critical Care and Sleep Medicine Division (T.P.R., D.H.I.), Center for Translational Medicine (C.M.F., B.J.N., N.A.L., L.G.C., B.L.K., M.A.M., R.J.S.), University of Minnesota, Minneapolis, Minnesota and Department of Pulmonary, Critical Care, Sleep Medicine and Respiratory Car
  • Norris BJ; Pulmonology, Allergy, Critical Care and Sleep Medicine Division (T.P.R., D.H.I.), Center for Translational Medicine (C.M.F., B.J.N., N.A.L., L.G.C., B.L.K., M.A.M., R.J.S.), University of Minnesota, Minneapolis, Minnesota and Department of Pulmonary, Critical Care, Sleep Medicine and Respiratory Car
  • Larson NA; Pulmonology, Allergy, Critical Care and Sleep Medicine Division (T.P.R., D.H.I.), Center for Translational Medicine (C.M.F., B.J.N., N.A.L., L.G.C., B.L.K., M.A.M., R.J.S.), University of Minnesota, Minneapolis, Minnesota and Department of Pulmonary, Critical Care, Sleep Medicine and Respiratory Car
  • Coicou LG; Pulmonology, Allergy, Critical Care and Sleep Medicine Division (T.P.R., D.H.I.), Center for Translational Medicine (C.M.F., B.J.N., N.A.L., L.G.C., B.L.K., M.A.M., R.J.S.), University of Minnesota, Minneapolis, Minnesota and Department of Pulmonary, Critical Care, Sleep Medicine and Respiratory Car
  • Koniar BL; Pulmonology, Allergy, Critical Care and Sleep Medicine Division (T.P.R., D.H.I.), Center for Translational Medicine (C.M.F., B.J.N., N.A.L., L.G.C., B.L.K., M.A.M., R.J.S.), University of Minnesota, Minneapolis, Minnesota and Department of Pulmonary, Critical Care, Sleep Medicine and Respiratory Car
  • Mysz MA; Pulmonology, Allergy, Critical Care and Sleep Medicine Division (T.P.R., D.H.I.), Center for Translational Medicine (C.M.F., B.J.N., N.A.L., L.G.C., B.L.K., M.A.M., R.J.S.), University of Minnesota, Minneapolis, Minnesota and Department of Pulmonary, Critical Care, Sleep Medicine and Respiratory Car
  • Rich TP; Pulmonology, Allergy, Critical Care and Sleep Medicine Division (T.P.R., D.H.I.), Center for Translational Medicine (C.M.F., B.J.N., N.A.L., L.G.C., B.L.K., M.A.M., R.J.S.), University of Minnesota, Minneapolis, Minnesota and Department of Pulmonary, Critical Care, Sleep Medicine and Respiratory Car
  • Ingbar DH; Pulmonology, Allergy, Critical Care and Sleep Medicine Division (T.P.R., D.H.I.), Center for Translational Medicine (C.M.F., B.J.N., N.A.L., L.G.C., B.L.K., M.A.M., R.J.S.), University of Minnesota, Minneapolis, Minnesota and Department of Pulmonary, Critical Care, Sleep Medicine and Respiratory Car
  • Schumacher RJ; Pulmonology, Allergy, Critical Care and Sleep Medicine Division (T.P.R., D.H.I.), Center for Translational Medicine (C.M.F., B.J.N., N.A.L., L.G.C., B.L.K., M.A.M., R.J.S.), University of Minnesota, Minneapolis, Minnesota and Department of Pulmonary, Critical Care, Sleep Medicine and Respiratory Car
J Pharmacol Exp Ther ; 376(1): 74-83, 2021 01.
Article in English | MEDLINE | ID: covidwho-894806
ABSTRACT
Acute respiratory distress syndrome (ARDS) is a severe, life-threatening form of respiratory failure characterized by pulmonary edema, inflammation, and hypoxemia due to reduced alveolar fluid clearance (AFC). Alveolar fluid clearance is required for recovery and effective gas exchange, and higher rates of AFC are associated with reduced mortality. Thyroid hormones play multiple roles in lung function, and L-3,5,3'-triiodothyronine (T3) has multiple effects on lung alveolar type II cells. T3 enhances AFC in normal adult rat lungs when administered intramuscularly and in normal or hypoxia-injured lungs when given intratracheally. The safety of a commercially available formulation of liothyronine sodium (synthetic T3) administered intratracheally was assessed in an Investigational New Drug Application-enabling toxicology study in healthy rats. Instillation of the commercial formulation of T3 without modification rapidly caused tracheal injury and often mortality. Intratracheal instillation of T3 that was reformulated and brought to a neutral pH at the maximum feasible dose of 2.73 µg T3 in 300 µl for 5 consecutive days had no clinically relevant T3-related adverse clinical, histopathologic, or clinical pathology findings. There were no unscheduled deaths that could be attributed to the reformulated T3 or control articles, no differences in the lung weights, and no macroscopic or microscopic findings considered to be related to treatment with T3. This preclinical safety study has paved the way for a phase I/II study to determine the safety and tolerability of a T3 formulation delivered into the lungs of patients with ARDS, including coronavirus disease 2019-associated ARDS, and to measure the effect on extravascular lung water in these patients. SIGNIFICANCE STATEMENT There is growing interest in treating lung disease with thyroid hormone [triiodothyronine (T3)] in pulmonary edema and acute respiratory distress syndrome (ARDS). However, there is not any published experience on the impact of direct administration of T3 into the lung. An essential step is to determine the safety of multiple doses of T3 administered in a relevant animal species. This study enabled Food and Drug Administration approval of a phase I/II clinical trial of T3 instillation in patients with ARDS, including coronavirus disease 2019-associated ARDS (T3-ARDS ClinicalTrials.gov Identifier NCT04115514).
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Distress Syndrome / Triiodothyronine / Instillation, Drug / Lung Type of study: Prognostic study / Randomized controlled trials Topics: Traditional medicine Limits: Animals Language: English Journal: J Pharmacol Exp Ther Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Distress Syndrome / Triiodothyronine / Instillation, Drug / Lung Type of study: Prognostic study / Randomized controlled trials Topics: Traditional medicine Limits: Animals Language: English Journal: J Pharmacol Exp Ther Year: 2021 Document Type: Article