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Robust neutralizing antibodies to SARS-CoV-2 infection persist for months.
Wajnberg, Ania; Amanat, Fatima; Firpo, Adolfo; Altman, Deena R; Bailey, Mark J; Mansour, Mayce; McMahon, Meagan; Meade, Philip; Mendu, Damodara Rao; Muellers, Kimberly; Stadlbauer, Daniel; Stone, Kimberly; Strohmeier, Shirin; Simon, Viviana; Aberg, Judith; Reich, David L; Krammer, Florian; Cordon-Cardo, Carlos.
  • Wajnberg A; Department of General Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. ania.wajnberg@mountsinai.org florian.krammer@mssm.edu carlos.cordon-cardo@mssm.edu.
  • Amanat F; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Firpo A; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Altman DR; Clinical Microbiology Laboratory, Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Bailey MJ; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Mansour M; Department of General Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • McMahon M; Department of General Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Meade P; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Mendu DR; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Muellers K; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Stadlbauer D; Clinical Microbiology Laboratory, Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Stone K; Department of General Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Strohmeier S; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Simon V; Department of General Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Aberg J; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Reich DL; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Krammer F; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Cordon-Cardo C; Department of Anesthesiology, Perioperative and Pain Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Science ; 370(6521): 1227-1230, 2020 12 04.
Article in English | MEDLINE | ID: covidwho-2243268
ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic with millions infected and more than 1 million fatalities. Questions regarding the robustness, functionality, and longevity of the antibody response to the virus remain unanswered. Here, on the basis of a dataset of 30,082 individuals screened at Mount Sinai Health System in New York City, we report that the vast majority of infected individuals with mild-to-moderate COVID-19 experience robust immunoglobulin G antibody responses against the viral spike protein. We also show that titers are relatively stable for at least a period of about 5 months and that anti-spike binding titers significantly correlate with neutralization of authentic SARS-CoV-2. Our data suggest that more than 90% of seroconverters make detectable neutralizing antibody responses. These titers remain relatively stable for several months after infection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antibodies, Neutralizing / SARS-CoV-2 / COVID-19 / Antibodies, Viral Limits: Humans Language: English Journal: Science Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antibodies, Neutralizing / SARS-CoV-2 / COVID-19 / Antibodies, Viral Limits: Humans Language: English Journal: Science Year: 2020 Document Type: Article