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Lack of Serologic Evidence of Infection Among Health Care Personnel and Other Contacts of First 2 Confirmed Patients With COVID-19 in Illinois, 2020.
McPherson, Tristan D; Ghinai, Isaac; Binder, Alison M; Freeman, Brandi D; Hoskin Snelling, Chantel; Hunter, Jennifer C; Anderson, Kristin M; Davenport, Polly; Rudd, Deborah L; Zafer, Mujeeb; Christiansen, Demian; Joshi, Kiran; Rubin, Rachel; Black, Stephanie R; Fricchione, Marielle J; Pacilli, Massimo; Walblay, Kelly A; Korpics, Jacqueline; Moeller, Darcie; Quartey-Kumapley, Pearl; Wang, Chen; Charles, E Matt; Kauerauf, Judy; Patel, Megan T; Disari, Vishal S; Fischer, Marc; Jacobs, Max W; Lester, Sandra N; Midgley, Claire M; Rasheed, Mohammed Ata Ur; Reese, Heather E; Verani, Jennifer R; Wallace, Megan; Watson, John T; Thornburg, Natalie J; Layden, Jennifer E; Kirking, Hannah L.
  • McPherson TD; 1242 Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Ghinai I; 11056 Chicago Department of Public Health, Chicago, IL, USA.
  • Binder AM; 1242 Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Freeman BD; 11056 Chicago Department of Public Health, Chicago, IL, USA.
  • Hoskin Snelling C; 7455 Illinois Department of Public Health, Springfield, IL, USA.
  • Hunter JC; 1242 National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Anderson KM; 1242 Laboratory Leadership Service, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Davenport P; 1242 National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Rudd DL; 7455 Illinois Department of Public Health, Springfield, IL, USA.
  • Zafer M; 1242 National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Christiansen D; 21862 AMITA Health, St. Alexius Medical Center, Hoffman Estates, IL, USA.
  • Joshi K; 21862 AMITA Health, St. Alexius Medical Center, Hoffman Estates, IL, USA.
  • Rubin R; 21862 AMITA Health, St. Alexius Medical Center, Hoffman Estates, IL, USA.
  • Black SR; 21862 AMITA Health, St. Alexius Medical Center, Hoffman Estates, IL, USA.
  • Fricchione MJ; 6144 Cook County Department of Public Health, Oak Forest, IL, USA.
  • Pacilli M; 6144 Cook County Department of Public Health, Oak Forest, IL, USA.
  • Walblay KA; 6144 Cook County Department of Public Health, Oak Forest, IL, USA.
  • Korpics J; 11056 Chicago Department of Public Health, Chicago, IL, USA.
  • Moeller D; 11056 Chicago Department of Public Health, Chicago, IL, USA.
  • Quartey-Kumapley P; 11056 Chicago Department of Public Health, Chicago, IL, USA.
  • Wang C; 11056 Chicago Department of Public Health, Chicago, IL, USA.
  • Charles EM; 6144 Cook County Health, Chicago, IL, USA.
  • Kauerauf J; Northwestern Feinberg School of Medicine, Chicago, IL, USA.
  • Patel MT; 6144 Cook County Health, Chicago, IL, USA.
  • Disari VS; Northwestern Feinberg School of Medicine, Chicago, IL, USA.
  • Fischer M; 6144 Cook County Health, Chicago, IL, USA.
  • Jacobs MW; 6144 Cook County Health, Chicago, IL, USA.
  • Lester SN; Northwestern Feinberg School of Medicine, Chicago, IL, USA.
  • Midgley CM; 7455 Illinois Department of Public Health, Springfield, IL, USA.
  • Rasheed MAU; 7455 Illinois Department of Public Health, Springfield, IL, USA.
  • Reese HE; 7455 Illinois Department of Public Health, Springfield, IL, USA.
  • Verani JR; 1242 National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Wallace M; Boonshoft School of Medicine, Wright State University, Dayton, OH, USA.
  • Watson JT; 1242 National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Thornburg NJ; 1242 National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Layden JE; Lake Erie College of Osteopathic Medicine, Erie, PA, USA.
  • Kirking HL; 1242 National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Public Health Rep ; 136(1): 88-96, 2021.
Article in English | MEDLINE | ID: covidwho-894953
Semantic information from SemMedBD (by NLM)
1. Confirmation PROCESS_OF Patients
Subject
Confirmation
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PROCESS_OF
Object
Patients
2. COVID-19 PROCESS_OF Patients
Subject
COVID-19
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PROCESS_OF
Object
Patients
3. COVID-19 CAUSES Contacts
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COVID-19
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CAUSES
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4. COVID-19 COEXISTS_WITH assessment.initial
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COVID-19
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COEXISTS_WITH
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assessment.initial
5. Antibodies PART_OF 2019 novel coronavirus
Subject
Antibodies
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PART_OF
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2019 novel coronavirus
6. Confirmation PROCESS_OF Patients
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Confirmation
Predicate
PROCESS_OF
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Patients
7. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
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Patients
8. COVID-19 CAUSES Contacts
Subject
COVID-19
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CAUSES
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Contacts
9. COVID-19 COEXISTS_WITH assessment.initial
Subject
COVID-19
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COEXISTS_WITH
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assessment.initial
10. Antibodies PART_OF 2019 novel coronavirus
Subject
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ABSTRACT

OBJECTIVES:

Widespread global transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus causing coronavirus disease 2019 (COVID-19), continues. Many questions remain about asymptomatic or atypical infections and transmission dynamics. We used comprehensive contact tracing of the first 2 confirmed patients in Illinois with COVID-19 and serologic SARS-CoV-2 antibody testing to determine whether contacts had evidence of undetected COVID-19.

METHODS:

Contacts were eligible for serologic follow-up if previously tested for COVID-19 during an initial investigation or had greater-risk exposures. Contacts completed a standardized questionnaire during the initial investigation. We classified exposure risk as high, medium, or low based on interactions with 2 index patients and use of personal protective equipment (PPE). Serologic testing used a SARS-CoV-2 spike enzyme-linked immunosorbent assay on serum specimens collected from participants approximately 6 weeks after initial exposure to either index patient. The 2 index patients provided serum specimens throughout their illness. We collected data on demographic, exposure, and epidemiologic characteristics.

RESULTS:

Of 347 contacts, 110 were eligible for serologic follow-up; 59 (17% of all contacts) enrolled. Of these, 53 (90%) were health care personnel and 6 (10%) were community contacts. Seventeen (29%) reported high-risk exposures, 15 (25%) medium-risk, and 27 (46%) low-risk. No participant had evidence of SARS-CoV-2 antibodies. The 2 index patients had antibodies detected at dilutions >16400 within 4 weeks after symptom onset.

CONCLUSIONS:

In serologic follow-up of the first 2 known patients in Illinois with COVID-19, we found no secondary transmission among tested contacts. Lack of seroconversion among these contacts adds to our understanding of conditions (ie, use of PPE) under which SARS-CoV-2 infections might not result in transmission and demonstrates that SARS-CoV-2 antibody testing is a useful tool to verify epidemiologic findings.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Contact Tracing / Occupational Exposure / Health Personnel / COVID-19 Type of study: Etiology study / Evidence synthesis / Risk factors Limits: Female / Humans / Male Country/Region as subject: North America Language: English Journal: Public Health Rep Year: 2021 Document Type: Article Affiliation country: 0033354920966064

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Contact Tracing / Occupational Exposure / Health Personnel / COVID-19 Type of study: Etiology study / Evidence synthesis / Risk factors Limits: Female / Humans / Male Country/Region as subject: North America Language: English Journal: Public Health Rep Year: 2021 Document Type: Article Affiliation country: 0033354920966064